Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.14.13.9

Official Name

kynurenine 3-monooxygenase

Name from literature

Kynurenine hydroxylase

Pathway from literature

tryptophan metabolism

Pathway from KEGG

Amino Acid Metabolism; Tryptophan metabolism; map00380

Organisms

Human (9606)

Genome localization

1q42-q44[8564 ],

Comments

A flavoprotein (FAD).

Rate-limiting Description

"Regulation of the rate-limiting step in dopamine (DA) synthesis was estimated in striatal synaptosomes by measuring the rate of hydroxylation of L-4-." (3Hphenylalanine, a substrate of tyrosine hydroxylase (TH))

"KM is innately low in the brain and similar in activity to indoleamine oxidase, the rate-limiting pathway enzyme." (10939276)

Regulatory Information

Regulatory type

Detail

phosphorylation;

O15229:from_uniprot:399_Phosphothreonine

phosphorylation;

O15229

Gene ontology

Gene ontology

GO:0019674 (P) NAD metabolic process [O15229 ];
GO:0016021 (C) integral to membrane [O15229 ];
GO:0009055 (F) electron carrier activity [O15229 ];
GO:0004502 (F) kynurenine 3-monooxygenase activity [O15229 ];
GO:0055114 (P) oxidation reduction [O15229 ];
GO:0005829 (C) cytosol [O15229 ];
GO:0005741 (C) mitochondrial outer membrane [O15229 ];

Tissue expression

Tissue From HPRD

Kidney [04642 ];
Heart [04642 ];
Lung [04642 ];
Pancreas [04642 ];
Liver [04642 ];
Skeletal muscle [04642 ];
Placenta [04642 ];
Brain [04642 ];

Tissue specificity

Highest levels in placenta and liver. Detectable in kidney [O15229 ];

Subcellular localization

Localization

mitochondrion [O15229 ];

Links

SwissProt

O15229

Entrez Gene

8564

HPRD

04642



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  Last Modified: 2009-03-24  
  Design by Zhao Min