Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

3.4.23.46

Official Name

memapsin 2

Name from literature

Beta-secretase

Pathway from literature

generation of the amyloid beta-peptide (Abeta) in Alzheimer disease

Pathway from KEGG

Human Diseases; Neurodegenerative Diseases; Alzheimer's disease; map05010

Organisms

Human (9606)

Genome localization

11q23.2-q23.3[23621 ],

Comments

Suggested to be the major "beta-secretase" responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. In peptidase family A1 but is atypical in containing a C-terminal membrane-spanning domain.

Rate-limiting Description

"Beta-secretase ." (beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is the key rate-limiting enzyme for the production of the beta-amyloid (Abeta) peptide involved in the pathogenesis of Alzheimer's disease (AD))

"Beta-secretase (BACE1) is the rate-limiting protease for the generation of the amyloid beta-peptide (Abeta) in Alzheimer disease." (15987683)

Regulatory Information

Upstream transcription factor

6667

Regulatory type

Detail

transcriptional factor;Sp1(6667)

"BACE1 gene expression is tightly regulated at the transcriptional level, and transcription factor Sp1 plays an important role in regulation of BACE1 to process APP generating Abeta in Alzheimer's disease." (14701757)

key enzyme;

"Beta-secretase (BACE-1), a key enzyme in the etiopathogenesis and progression of Alzheimer disease, is the focus of medicinal chemistry efforts both in the pharmaceutical industry and in academia." (17407105)

transcriptional factor;Sp1(6667)

"BACE1 gene expression is tightly regulated at the transcriptional level, and transcription factor Sp1 plays an important role in regulation of BACE1 to process APP generating Abeta in Alzheimer's disease." (14701757)

phosphorylation;PKC

"Stimulation of cells with muscarinic agonists increased BACE1 expression up to twofold over basal levels. Similar effects of BACE1 up-regulation were observed when protein kinase C was directly activated by phorbol esters." (15211591)

phosphorylation;

P56817

Gene ontology

Gene ontology

GO:0008798 (F) beta-aspartyl-peptidase activity [P56817 ];
GO:0050435 (P) beta-amyloid metabolic process [P56817 ];
GO:0006509 (P) membrane protein ectodomain proteolysis [P56817 ];
GO:0005887 (C) integral to plasma membrane [P56817 ];
GO:0005768 (C) endosome [P56817 ];
GO:0005794 (C) Golgi apparatus [P56817 ];
GO:0004190 (F) aspartic-type endopeptidase activity [P56817 ];

Tissue expression

Tissue From HPRD

Colon [07255 ];
Cerebral cortex [07255 ];
Leukocyte [07255 ];
Muscle fibre [07255 ];
Liver [07255 ];
Muscle [07255 ];
Brain [07255 ];
Spleen [07255 ];
Prostate [07255 ];
Cerebral neuron [07255 ];
Small intestine [07255 ];
Kidney [07255 ];
Lung [07255 ];
Heart [07255 ];
Ovary [07255 ];
Pancreas [07255 ];
Placenta [07255 ];
Thyroid gland [07255 ];

Tissue specificity

Brain [P56817 ];

Subcellular localization

Localization

cell membrane [P56817 ];

Links

SwissProt

P56817

Entrez Gene

23621

HPRD

07255



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  Last Modified: 2009-03-24  
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