Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.7.7.15

Official Name

choline-phosphate cytidylyltransferase

Name from literature

Choline-phosphate cytidylyltransferase

Pathway from literature

membrane phospholipid synthesis

Pathway from KEGG

Metabolism of Other Amino Acids; Aminophosphonate metabolism; map00440

Lipid Metabolism; Glycerophospholipid metabolism; map00564

Organisms

Human (9606)

Genome localization

3q29[5130 ], Xp22.11[9468 ],

Rate-limiting Description

"Elevated PME could be secondary to a metabolic block at the rate-limiting enzyme in membrane phospholipid synthesis, which is cytidine triphosphate (CTP): phosphocholine (or phosphoethanolamine) cytidyltransferase (EC 2.7.7.15)." (3367156)

"The activity of membrane-bound CTP:phosphocholine cytidylyltransferase, the rate-limiting enzyme, was increased by 47 +/- 4% in cholesterol-enriched cells whereas its activity was unchanged in lathosterol-enriched cells." (11029581)

Regulatory Information

Regulatory type

Detail

phosphorylation;

"Like CCTalpha, CCTbeta2 is heavily phosphorylated in vivo, in contrast to CCTbeta1." (10480912)

transcriptional level;"TNF-alpha(7124),"

"we demonstrated that tumor necrosis factor (TNF)-alpha inhibited the activity of CTP:phosphocholine cytidylyltransferase (CT), the rate-limiting enzyme in the de novo synthesis of phosphatidylcholine (PC), and that its actions were likely exerted through a metabolite of sphingomyelin." (11404253)

regulatory enzyme;

"Cytidylyltransferase (CTP: cholinephosphate cytidylyltransferase, EC 2.7.7.15, CYT) is a regulatory enzyme for synthesis of pulmonary surfactant phosphatidylcholine (PC). " (8218341)

phosphorylation;

P49585

phosphorylation;

Q9Y5K3

phosphorylation;

P49585:from_uniprot:315_Phosphoserine

phosphorylation;

P49585:from_uniprot:319_Phosphoserine

phosphorylation;

P49585:from_uniprot:329_Phosphoserine

phosphorylation;

P49585:from_uniprot:331_Phosphoserine

phosphorylation;

P49585:from_uniprot:347_Phosphoserine

phosphorylation;

P49585:from_uniprot:362_Phosphoserine

phosphorylation;

Q9Y5K3:from_uniprot:315_Phosphoserine

phosphorylation;

Q9Y5K3:from_uniprot:319_Phosphoserine

phosphorylation;

Q9Y5K3:from_uniprot:325_Phosphothreonine

Gene ontology

Gene ontology

GO:0005783 (C) endoplasmic reticulum [Q9Y5K3 ];
GO:0006656 (P) phosphatidylcholine biosynthetic process [Q9Y5K3 ];
GO:0005625 (C) soluble fraction [P49585 ];
GO:0004105 (F) choline-phosphate cytidylyltransferase acti... [P49585, Q9Y5K3 ];

Tissue expression

Tissue From HPRD

Thymus [05376 ];
Colon [05376 ];
Ubiquitous [00438 ];
Fetus [05376 ];
Leukocyte [05376 ];
Testis [05376 ];
Skeletal muscle [05376 ];
Liver [05376 ];
Brain [05376 ];
Spleen [05376 ];
Reticulocyte [05376 ];
Prostate [05376 ];
Small intestine [05376 ];
Kidney [05376 ];
Lung [05376 ];
Heart [05376 ];
Ovary [05376 ];
Pancreas [05376 ];
Placenta [05376 ];

Tissue specificity

Highly expressed in testis, placenta, brain, ovary and fetus [Q9Y5K3 ];

Subcellular localization

Localization

cell membrane [P49585 ];

endoplasmic reticulum [Q9Y5K3 ];

cytoplasm [P49585 ];

Links

SwissProt

P49585; Q9Y5K3

Entrez Gene

5130; 9468

HPRD

00438; 05376



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min