Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.7.7.14

Official Name

ethanolamine-phosphate cytidylyltransferase

Name from literature

phosphoethanolamine cytidylyltransferase

Pathway from literature

phosphatidylethanolamine synthesis

Pathway from KEGG

Metabolism of Other Amino Acids; Aminophosphonate metabolism; map00440

Lipid Metabolism; Glycerophospholipid metabolism; map00564

Organisms

Human (9606)

Rate-limiting Description

"In contrast, the activity of phosphoethanolamine cytidylyltransferase (PECT), the rate-limiting enzyme of phosphatidylethanolamine synthesis, was significantly and markedly decreased by 35%-78% in the cerebellar, frontal, and occipital cortices of patients with FA but was normal in SCA-1." (10752579)

Regulatory Information

Upstream transcription factor

6667;4790

Regulatory type

Detail

regulatory enzyme;

"Phosphoethanolamine is the substrate of the regulatory enzyme CTP:phosphoethanolamine cytidylyltransferase (ECT) in the de novo biosynthesis of phosphatidylethanolamine (PE)." (18583706)

transcriptional factor;"CAAT,Sp1(6667),NF1 family"

"There is no sequence homology between the two promoters but they are both TATA-less, have conserved CAAT boxes at a matching distance (-85/-70 bp) from the transcription start site and contain cis-elements for transcription factors of the CAAT, Sp1 and NF1 family, all in accordance with ubiquitous expression of both genes. " (14697519)

transcriptional factor;NFkappaB(4790)

"In MCF-7 cells, EGR1 is present at lower levels and the basal PCYT2 promoter activity is maintained by proximal CAAT and GC regions and by elevated nuclear NFkappaB activity. Together, these data demonstrate that EGR1 is an important transcriptional stimulator of the human PCYT2 and that conditions that modify EGR1 also affect the function of ECT and consequently PE synthesis." (18583706)

Gene ontology

Gene ontology

GO:0004306 (F) ethanolamine-phosphate cytidylyltransferase... [Q99447 ];
GO:0008654 (P) phospholipid biosynthetic process [Q99447 ];

Tissue expression

Tissue From HPRD

Lung [04059 ];
Heart [04059 ];
Pancreas [04059 ];
Skeletal muscle [04059 ];
Liver [04059 ];
Kidney [04059 ];
Brain [04059 ];

Tissue specificity

Strongest expression in liver, heart, and skeletal muscle [Q99447 ];

Links

SwissProt

Q99447

Entrez Gene

5833

HPRD

04059



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  Last Modified: 2009-03-24  
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