Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

3.1.3.25

Official Name

inositol-phosphate phosphatase

Name from literature

Myo-inositol-1-phosphate (MIP) synthase

Pathway from literature

inositol biosynthesis

Pathway from KEGG

Environmental Information Processing; Signal Transduction; Phosphatidylinositol signaling system; map04070

Carbohydrate Metabolism; Inositol phosphate metabolism; map00562

Biosynthesis of Secondary Metabolites; Streptomycin biosynthesis; map00521

Organisms

Human (9606)

Genome localization

8q21.13-q21.3[3612 ], 18p11.2[3613 ],

Comments

Acts on five of the six isomers of myo-inositol phosphate, all except myo-inositol 2-phosphate, but does not act on myo-inositol bearing more than one phosphate group. It also acts on adenosine 2'-phosphate (but not the 3'- or 5'- phosphates), sn-glycerol 3-phosphate and glycerol 2-phosphate. Two isoforms are known [4].

Rate-limiting Description

"MIP synthase is the rate-limiting step in inositol biosynthesis and is highly regulated in response to inositol." (12479670)

Regulatory Information

Regulatory type

Detail

phosphorylation;

P29218

Gene ontology

Gene ontology

GO:0000287 (F) magnesium ion binding [P29218, O14732, Q9NX62 ];
GO:0006796 (P) phosphate metabolic process [P29218, O14732 ];
GO:0031403 (F) lithium ion binding [P29218 ];
GO:0005737 (C) cytoplasm [P29218 ];
GO:0007165 (P) signal transduction [P29218, O14732 ];
GO:0005794 (C) Golgi apparatus [Q9NX62 ];
GO:0005975 (P) carbohydrate metabolic process [P29218 ];
GO:0016021 (C) integral to membrane [Q9NX62 ];
GO:0005634 (C) nucleus [Q9NX62 ];
GO:0006661 (P) phosphatidylinositol biosynthetic process [P29218 ];
GO:0008934 (F) inositol-1(or 4)-monophosphatase activity [P29218, O14732, Q9NX62 ];

Subcellular localization

Localization

membrane [Q9NX62 ];

cytoplasm [P29218 ];

Disease relevance

Disease

The blockade of inositol monophosphatase hydrolysis may underlie the anti-manic and anti-depressant actions of Li(+) [P29218 ];

Links

SwissProt

O14732; P29218; Q9NX62

Entrez Gene

3612; 3613

HPRD

09329; 03641



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  Last Modified: 2009-03-24  
  Design by Zhao Min