Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

3.1.1.7

Official Name

acetylcholinesterase

Name from literature

acetylcholinesterase

Pathway from literature

acylation with certain substrates precedes general acid-base catalysis

Pathway from KEGG

Lipid Metabolism; Glycerophospholipid metabolism; map00564

Organisms

Human (9606)

Genome localization

7q22[43 ],

Comments

Acts on a variety of acetic esters; also catalyses transacetylations.

Rate-limiting Description

"Hydrolysis of the neurotransmitter acetylcholine by acetylcholinesterase (ACHE) and butyrylcholinesterase (BCHE) is the rate-limiting step in the termination of cholinergic signaling at neuromuscular junctions." (1820094)

Regulatory Information

Upstream transcription factor

1386;3725

Regulatory type

Detail

transcriptional level;

"Forskolin, an inducer of cAMP, up-regulates acetylcholinesterase expression and protects against organophosphate exposure in neuro 2A cells." (16924422)

phosphorylation;

"human erythrocyte acetylcholinesterase phosphorylated by tabun." (17562604)

regulatory enzyme;

"The distribution of the major cholinergic regulatory enzyme acetylcholinesterase (AChE, EC 3.1.1.7) has been extensively studied in the human brain, but the distribution of the closely related enzyme butyrylcholinesterase (BuChE, EC 3.1.1.8) is largely unknown. " (9548556)

transcriptional factor;c-jun(3725),ATF2(1386)

"Mutation analysis indicates that the major response elements for JNK in the AChE promoter are the AP1-like element (TGAGTCT) site, located within the -1565/-1569 region of the AChE promoter, and the ATF2 element (CCACGTCA), within the -2185/-2177 region. The AP1-like element binds to the transcription factors, c-jun and ATF2, while the ATF2 element binds mainly ATF2. Taken together, our results strongly suggest that H2O2 induces AChE expression via the JNK/AP1/ ATF2 signaling pathway." (18385943)

Gene ontology

Gene ontology

GO:0004104 (F) cholinesterase activity [P22303 ];
GO:0042982 (P) amyloid precursor protein metabolic process [P22303 ];
GO:0007416 (P) synaptogenesis [P22303 ];
GO:0043237 (F) laminin-1 binding [P22303 ];
GO:0017171 (F) serine hydrolase activity [P22303 ];
GO:0002076 (P) osteoblast development [P22303 ];
GO:0045202 (C) synapse [P22303 ];
GO:0005794 (C) Golgi apparatus [P22303 ];
GO:0001540 (F) beta-amyloid binding [P22303 ];
GO:0005518 (F) collagen binding [P22303 ];
GO:0007155 (P) cell adhesion [P22303 ];
GO:0006260 (P) DNA replication [P22303 ];
GO:0009611 (P) response to wounding [P22303 ];
GO:0042166 (F) acetylcholine binding [P22303 ];
GO:0008283 (P) cell proliferation [P22303 ];
GO:0042803 (F) protein homodimerization activity [P22303 ];
GO:0031225 (C) anchored to membrane [P22303 ];
GO:0030054 (C) cell junction [P22303 ];
GO:0003990 (F) acetylcholinesterase activity [P22303 ];
GO:0001507 (P) acetylcholine catabolic process in synaptic... [P22303 ];
GO:0032223 (P) negative regulation of synaptic transmissio... [P22303 ];
GO:0005605 (C) basal lamina [P22303 ];
GO:0048471 (C) perinuclear region of cytoplasm [P22303 ];
GO:0007517 (P) muscle development [P22303 ];
GO:0005634 (C) nucleus [P22303 ];
GO:0050714 (P) positive regulation of protein secretion [P22303 ];

Tissue expression

Tissue From HPRD

Nervous system [00010 ];
Thalamus [00010 ];
Osteoblast [00010 ];
Liver [00010 ];
Blood [00010 ];
Retina [00010 ];
Brain [00010 ];
Muscle [00010 ];
B Cell [00010 ];

Tissue specificity

Isoform H is highly expressed in erythrocytes [P22303 ];

Subcellular localization

Localization

extracellular [P22303 ];

cell membrane [P22303 ];

synapse [P22303 ];

nucleus [P22303 ];

Disease relevance

Disease

Behaves as an amyloid-promoting factor to promote the formation of amyloid plaques in Alzheimer disease [P22303 ];

Links

SwissProt

P22303

Entrez Gene

43

HPRD

00010



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  Last Modified: 2009-03-24  
  Design by Zhao Min