Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

3.1.1.8

Official Name

cholinesterase

Name from literature

butyrylcholinesterase

Pathway from literature

hydrolysis of the positively charged oxoester benzoylcholine ( BzCh )/termination of cholinergic signaling at neuromuscular junctions

Organisms

Human (9606)

Genome localization

3q26.1-q26.2[590 ],

Comments

Acts on a variety of choline esters and a few other compounds.

Rate-limiting Description

"Hydrolysis of the neurotransmitter acetylcholine by acetylcholinesterase (ACHE) and butyrylcholinesterase (BCHE) is the rate-limiting step in the termination of cholinergic signaling at neuromuscular junctions." (1820094)

Regulatory Information

Regulatory type

Detail

phosphorylation;

"Effect of temperature and pH on carbamoylation and phosphorylation of serum cholinesterases. Theoretical interpretation of activation energies in complex reactions." (4677141)

Gene ontology

Gene ontology

GO:0050783 (P) cocaine metabolic process [P06276 ];
GO:0001540 (F) beta-amyloid binding [P06276 ];
GO:0016020 (C) membrane [P06276 ];
GO:0005576 (C) extracellular region [P06276 ];
GO:0004104 (F) cholinesterase activity [P06276 ];
GO:0019899 (F) enzyme binding [P06276 ];

Tissue expression

Tissue From HPRD

Plasma [01519 ];
Brain [01519 ];
Fetus [01519 ];

Tissue specificity

Present in most cells except erythrocytes [P06276 ];

Disease relevance

Disease

Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait [P06276 ];

Links

SwissProt

P06276

Entrez Gene

590

HPRD

01519



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  Last Modified: 2009-03-24  
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