Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

6.3.4.2

Official Name

CTP synthase

Name from literature

Cytidine triphosphate synthetase

Pathway from literature

the de novo synthesis of CTP

Pathway from KEGG

Nucleotide Metabolism; Pyrimidine metabolism; map00240

Organisms

Human (9606)

Genome localization

Xp22[56474 ], 1p34.1[1503 ],

Comments

Glutamine can replace NH3.

Rate-limiting Description

"Cytidine triphosphate synthetase (CTPS) catalyzes the rate-limiting step in the de novo synthesis of CTP, and both the yeast and human enzymes have been reported to be regulated by protein kinase A or protein kinase C phosphorylation." (17681942)

Regulatory Information

Regulatory type

Detail

phosphorylation;PKA

"CTP synthetase is phosphorylated by protein kinase A" (16179339)

phosphorylation;PKC

"Data indicate that protein kinase C phosphorylation at Ser(462) stimulates human CTP synthetase 1 activity, whereas phosphorylation at Thr(455) inhibits activity." (17463002)

phosphorylation;GSK3

"analysis of phosphorylation and regulation of human CTPS1 in human cells shows that GSK3 is a novel regulator of CTPS activity" (17681942)

phosphorylation;

P17812:from_uniprot:562_Phosphoserine

phosphorylation;

P17812:from_uniprot:566_Phosphothreonine

phosphorylation;

P17812:from_uniprot:567_Phosphotyrosine

phosphorylation;

P17812:from_uniprot:568_Phosphoserine

phosphorylation;

P17812:from_uniprot:571_Phosphoserine

phosphorylation;

P17812:from_uniprot:573_Phosphoserine

phosphorylation;

P17812:from_uniprot:574_Phosphoserine

phosphorylation;

P17812:from_uniprot:575_Phosphoserine

phosphorylation;

Q9NRF8:from_uniprot:568_Phosphoserine

phosphorylation;

Q9NRF8:from_uniprot:571_Phosphoserine

phosphorylation;

Q9NRF8:from_uniprot:574_Phosphoserine

phosphorylation;

P17812

phosphorylation;

Q9NRF8

Gene ontology

Gene ontology

GO:0042493 (P) response to drug [P17812 ];
GO:0006541 (P) glutamine metabolic process [Q9NRF8, P17812 ];
GO:0003883 (F) CTP synthase activity [Q9NRF8, P17812 ];
GO:0005829 (C) cytosol [P17812 ];
GO:0005515 (F) protein binding [P17812 ];
GO:0006221 (P) pyrimidine nucleotide biosynthetic process [Q9NRF8 ];
GO:0006241 (P) CTP biosynthetic process [P17812 ];

Links

SwissProt

P17812; Q9NRF8

Entrez Gene

1503; 56474

HPRD

02305; 00465



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min