Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.1.15

Official Name

glycerol-3-phosphate O-acyltransferase

Name from literature

sn glycerol phosphate acyl transferase

Pathway from literature

Pathway from KEGG

Lipid Metabolism; Glycerolipid metabolism; map00561

Lipid Metabolism; Glycerophospholipid metabolism; map00564

Organisms

Human (9606)

Genome localization

10q25.2[57678 ],

Comments

Acyl-[acyl-carrier protein] can also act as acyl donor. The enzyme acts only on derivatives of fatty acids of chain length above C10

Rate-limiting Description

"Further analysis of the glycerol 3-phosphate pathway showed that the rate-limiting enzyme activities for diacylglycerol conversion to triacylglycerol, diacylglycerol acyltransferase, and phosphatidylcholine, CTP:phosphocholine cytidylyltransferase, increased 2-3-fold and decreased approximately 40%, respectively, during Caco-2 differentiation." (8387510)

Regulatory Information

Upstream transcription factor

6720

Regulatory type

Detail

inhibitor;

"Inhibition of glycerol-3-phosphate acyltransferase as a potential treatment for insulin resistance and type 2 diabetes." (15134282)

key enzyme;

"Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis." (17170135)

transcriptional factor;SREBP-1(6720)

"SREBP-1 is also a transcription factor for lipogenic genes, such as stearoyl coenzyme-A desaturase1 (SCD1), glycerol-3-phosphate acyltransferase (GPAT), and acetyl-CoA carboxylase (ACC)1, and ACC2. Genistein also significantly inhibited the expression of these lipogenic genes." (17449569#9054427)

phosphorylation;

Q9HCL2

phosphorylation;

Q9HCL2:from_uniprot:111_Phosphotyrosine

phosphorylation;

Q9HCL2:from_uniprot:695_Phosphoserine

Gene ontology

Gene ontology

GO:0008654 (P) phospholipid biosynthetic process [Q9HCL2, Q6NUI2 ];
GO:0016021 (C) integral to membrane [Q9HCL2, Q6NUI2 ];
GO:0005829 (C) cytosol [Q9HCL2 ];
GO:0005741 (C) mitochondrial outer membrane [Q9HCL2 ];
GO:0004366 (F) glycerol-3-phosphate O-acyltransferase acti... [Q9HCL2, Q6NUI2 ];

Subcellular localization

Localization

mitochondrion [Q9HCL2 ];

membrane [Q6NUI2 ];

Links

SwissProt

Q6NUI2; Q9HCL2

Entrez Gene

57678

HPRD

03865



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  Last Modified: 2009-03-24  
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