Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.1.99.5

Official Name

glycerol-3-phosphate dehydrogenase

Name from literature

glycerol phosphate dehydrogenase

Pathway from literature

glycerol phosphate shuttle

Pathway from KEGG

Lipid Metabolism; Glycerophospholipid metabolism; map00564

Organisms

Human (9606)

Genome localization

2q24.1[2820 ],

Rate-limiting Description

"Mitochondrial glycerol phosphate dehydrogenase (mtGPD) is the rate-limiting enzyme in the glycerol phosphate shuttle, which is thought to play an important role in cells that require an active glycolytic pathway." (8682323)

Regulatory Information

Regulatory type

Detail

transcriptional factor;

"observations seem to indicate that the rate of transcription, as well as the tissue-specific expression of the human mtGPDH gene, is the result of a combinatorial effect of transcription factors on at least two promoters." (11106433#16849634)

key enzyme;

"Our studies revealed that 5-n-alk(en)ylresorcinols isolated from wheat and rye bran inhibit glycerol-3-phosphate dehydrogenase, the key enzyme in triglyceride synthesis in adipocytes, specifically and effectively." (14733503#8579375)

others;

"the up-regulation of mGPDH, due to a highly glycolytic environment, contributes to the overall increase in ROS generation and may result in the progression of prostate cancer" (17886033)

phosphorylation;

P43304

phosphorylation;

P43304:from_uniprot:600_Phosphotyrosine

phosphorylation;

P43304:from_uniprot:601_Phosphotyrosine

Gene ontology

Gene ontology

GO:0006072 (P) glycerol-3-phosphate metabolic process [P43304 ];
GO:0004368 (F) glycerol-3-phosphate dehydrogenase activity [P43304 ];
GO:0009331 (C) glycerol-3-phosphate dehydrogenase complex [P43304 ];
GO:0055114 (P) oxidation reduction [P43304 ];
GO:0005509 (F) calcium ion binding [P43304 ];

Subcellular localization

Localization

mitochondrion [P43304 ];

Links

SwissProt

P43304

Entrez Gene

2820

HPRD

00715



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  Last Modified: 2009-03-24  
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