Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.1.67

Official Name

1-alkylglycerophosphocholine O-acetyltransferase

Name from literature

acetyl-CoA : lyso PAF acetyltransferase

Pathway from literature

Platelet activating factor biosynthesis

Pathway from KEGG

Lipid Metabolism; Ether lipid metabolism; map00565

Organisms

Human (9606)

Rate-limiting Description

"Theophylline and MIX lacked any inhibitory effect on acetyl-CoA: lyso-PAF acetyltransferase activity, which is the rate-limiting step for PAF biosynthesis in PMN." (1693077)

"Thrombin-stimulated endothelial cells produce platelet-activating factor (PAF) in a dose-dependent manner: the activation of a Ca2+-dependent lyso-PAF acetyltransferase is the rate-limiting step in this process." (2848827)

Regulatory Information

Regulatory type

Detail

phosphorylation;p38 MAPK

"A key enzyme of PAF synthesis, acetyl-CoA:lysoPAF acetyltransferase, which we have previously shown is a target of p38 MAPK, was also activated in an SB 203580-sensitive fashion." (15863359)

key enzyme;

"A key enzyme of PAF synthesis, acetyl-CoA:lysoPAF acetyltransferase, which we have previously shown is a target of p38 MAPK, was also activated in an SB 203580-sensitive fashion." (15863359)

Gene ontology

Gene ontology

GO:0047192 (F) 1-alkylglycerophosphocholine O-acetyltransf... [A3KBM1 ];
GO:0008152 (P) metabolic process [A3KBM1 ];
GO:0005509 (F) calcium ion binding [A3KBM1 ];

Links

SwissProt

A3KBM1

Entrez Gene

54947



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min