Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.3.3.1

Official Name

dihydroorotate oxidase

Name from literature

dihydro orotate dehydrogenase

Pathway from literature

de novo synthesis of pyrimidines and progression of the cell cycle in different cell lines,mainly activated T lymphocytes

Pathway from KEGG

Nucleotide Metabolism; Pyrimidine metabolism; map00240

Organisms

Human (9606)

Genome localization

16q22[1723 ],

Comments

A flavoprotein (FAD, FMN). Ferricyanide can act as acceptor.

Rate-limiting Description

"OBJECTIVES:: Life-threatening toxic side-effects following 5-FU exposure have been related to deficiency of dihydropyrimidine dehydrogenase (DPD), the rate-limiting enzyme in its catabolism." (17046731)

"DPYD encodes dihydropyrimidine dehydrogenase (DPD), which is the first and rate-limiting enzyme in a three-step metabolic pathway involved in degradation of the pyrimidine bases uracil and thymine." (16556484)

"Through the use of pharmacogenetic studies, interindividual variability in response (efficacy and toxicity) to 5-fluorouracil (5-FU) chemotherapy has been linked to the rate-limiting enzyme in the drug's catabolic pathway, known as dihydropyrimidine dehydrogenase (DPD)." (16163233)

Regulatory Information

Regulatory type

Detail

feedback;

"This paper reports results on a series of pyrimidine analogs of dihydroorotate (DHO) and orotic acid (OA) as inhibitors of DHO-dehase." (2847745)

Gene ontology

Gene ontology

GO:0004158 (F) dihydroorotate oxidase activity [Q02127 ];
GO:0006207 (P) 'de novo' pyrimidine base biosynthetic process [Q02127 ];
GO:0006222 (P) UMP biosynthetic process [Q02127 ];
GO:0055114 (P) oxidation reduction [Q02127 ];
GO:0005743 (C) mitochondrial inner membrane [Q02127 ];

Subcellular localization

Localization

mitochondrion [Q02127 ];

Links

SwissProt

Q02127

Entrez Gene

1723

HPRD

00521



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  Last Modified: 2009-03-24  
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