Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.1.85

Official Name

fatty-acid synthase

Name from literature

fatty acid synthase

Pathway from literature

fatty acid biosynthetic pathway

Pathway from KEGG

Cellular Processes; Endocrine System; Insulin signaling pathway; map04910

Lipid Metabolism; Fatty acid biosynthesis; map00061

Organisms

Human (9606)

Genome localization

17q25[2194 ],

Comments

The animal enzyme is a multi-functional protein catalysing the reactions of EC 2.3.1.38 [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39 [acyl-carrier-protein] S-malonyltransferase, EC 2.3.1.41 3-oxoacyl-[acyl-carrier-protein] synthase, EC 1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase, EC 4.2.1.61 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) and EC 3.1.2.14 oleoyl-[acyl-carrier-protein] hydrolase.

Rate-limiting Description

"Work in this issue of Cell Metabolism (Najjar at al., 2005) suggests a new mechanism for the inhibition of the rate-limiting enzyme in liver, fatty acid synthase.." (16054091)

Regulatory Information

Upstream transcription factor

2130;6720;3091

Regulatory type

Detail

phosphorylation;

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." (15302935#17081983#16964243)

others;insulin

"Regions responsible for hormonal regulation of the FAS gene lie in the proximal portion of the gene's 5'-flanking region, within which we identified an insulin response element." (15113941)

others;

"study reveals for the first time that extracellular acidosis can work in an epigenetic fashion by up-regulating the transcriptional expression of FAS gene" (15523670)

inhibitor;

"By using cerulenin and C75, two known inhibitors of FAS we were able to significantly block CVB3 replication." (17662476)

transcriptional factor;"HIF1(3091),SREBP-1(6720)"

"FAS gene is up-regulated by hypoxia via activation of the Akt and HIF1 followed by the induction of the SREBP-1 gene, and that hypoxia-induced chemoresistance is partly due to the up-regulation of FAS." (18281474)

phosphorylation;

P49327

phosphorylation;

P49327:from_uniprot:2204_Phosphothreonine

interact with TF;EWSR1(2130)

"Towards a proteome-scale map of the human protein-protein interaction network." (16189514)

Gene ontology

Gene ontology

GO:0048037 (F) cofactor binding [P49327 ];
GO:0008270 (F) zinc ion binding [P49327 ];
GO:0004319 (F) enoyl- [acyl-carrier-protein] reductase (NAD... [P49327 ];
GO:0004315 (F) 3-oxoacyl- [acyl-carrier-protein] synthase a... [P49327 ];
GO:0005829 (C) cytosol [P49327 ];
GO:0005794 (C) Golgi apparatus [P49327 ];
GO:0004317 (F) 3-hydroxypalmitoyl- [acyl-carrier-protein] d... [P49327 ];
GO:0042470 (C) melanosome [P49327 ];
GO:0005515 (F) protein binding [P49327 ];
GO:0004316 (F) 3-oxoacyl- [acyl-carrier-protein] reductase ... [P49327 ];
GO:0031177 (F) phosphopantetheine binding [P49327 ];
GO:0004313 (F) [acyl-carrier-protein] S-acetyltransferase ... [P49327 ];
GO:0000036 (F) acyl carrier activity [P49327 ];
GO:0006633 (P) fatty acid biosynthetic process [P49327 ];
GO:0004320 (F) oleoyl- [acyl-carrier-protein] hydrolase act... [P49327 ];
GO:0004314 (F) [acyl-carrier-protein] S-malonyltransferase... [P49327 ];
GO:0055114 (P) oxidation reduction [P49327 ];

Tissue expression

Tissue From HPRD

Colon [02567 ];
Duodenum epithelium [02567 ];
Zona fasciculata [02567 ];
Large intestine [02567 ];
Fetus [02567 ];
Vermiform appendix [02567 ];
Urinary bladder [02567 ];
Hepatocyte [02567 ];
Liver [02567 ];
Urothelium [02567 ];
Decidua [02567 ];
Adenohypophysis [02567 ];
Brain [02567 ];
Prostate [02567 ];
Epididymis [02567 ];
Cerebral neuron [02567 ];
Lactiferous duct [02567 ];
Astrocyte [02567 ];
Mammary gland [02567 ];
Seminiferous tubule [02567 ];
Endometrium [02567 ];
Lung [02567 ];
Mast cell [02567 ];
Cerebellum [02567 ];
Adrenal cortex [02567 ];
Adipocyte [02567 ];
Stomach [02567 ];
Sebaceous gland [02567 ];

Tissue specificity

Ubiquitous. Prominent expression in brain, lung, and liver [P49327 ];

Subcellular localization

Localization

cytoplasm [P49327 ];

Links

SwissProt

P49327

Entrez Gene

2194

HPRD

02567



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  Last Modified: 2009-03-24  
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