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| Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases |
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Basic Information |
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Enzyme Number | 2.7.1.137 |
Official Name | phosphatidylinositol 3-kinase |
Name from literature | PI kinase |
Pathway from literature | phosphatidylcholine synthesis |
Pathway from KEGG |
Environmental Information Processing; Signal Transduction; Phosphatidylinositol signaling system; map04070 |
| Carbohydrate Metabolism; Inositol phosphate metabolism; map00562 | |
| Genetic Information Processing; Folding, Sorting and Degradation; Regulation of autophagy; map04140 | |
Organisms | Human (9606) |
Genome localization | 18q12.3[5289 ], |
Comments | One mammalian isoform is known. |
Rate-limiting Description | "Moreover, transient expression of dominant-negative and wild-type phosphatidylinositol 3-OH kinase (PI 3-kinase) subunits, as well as application of specific inhibitors, demonstrates that PI 3-kinase is an essential and rate-limiting messenger in this signaling pathway." (9292730) |
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Regulatory Information |
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Upstream transcription factor | |
Regulatory type | Detail |
key enzyme; | "Although it is now well established that PI3K (phosphoinositide 3-kinase) is a key enzyme in several intracellular processes, there are still relatively few reports that precisely identify the specific isoforms of PI3K actually involved in such events." (17371240) |
transcriptional factor;POU-type transcription factor(5460) | "A promoter mutation in a PI regulator affecting the binding of a POU-type transcription factor may be involved in BD and SZ in a subset of patients." (15121481) |
phosphorylation; | Q8NEB9 |
phosphorylation; | Q8NEB9:from_uniprot:525_Phosphoserine |
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Gene ontology |
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Gene ontology |
GO:0030145 (F) manganese ion binding [Q8NEB9 ]; |
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Links |
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SwissProt | |
Entrez Gene | |
HPRD |