Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.7.1.137

Official Name

phosphatidylinositol 3-kinase

Name from literature

PI kinase

Pathway from literature

phosphatidylcholine synthesis

Pathway from KEGG

Environmental Information Processing; Signal Transduction; Phosphatidylinositol signaling system; map04070

Carbohydrate Metabolism; Inositol phosphate metabolism; map00562

Genetic Information Processing; Folding, Sorting and Degradation; Regulation of autophagy; map04140

Organisms

Human (9606)

Genome localization

18q12.3[5289 ],

Comments

One mammalian isoform is known.

Rate-limiting Description

"Moreover, transient expression of dominant-negative and wild-type phosphatidylinositol 3-OH kinase (PI 3-kinase) subunits, as well as application of specific inhibitors, demonstrates that PI 3-kinase is an essential and rate-limiting messenger in this signaling pathway." (9292730)

Regulatory Information

Upstream transcription factor

5460

Regulatory type

Detail

key enzyme;

"Although it is now well established that PI3K (phosphoinositide 3-kinase) is a key enzyme in several intracellular processes, there are still relatively few reports that precisely identify the specific isoforms of PI3K actually involved in such events." (17371240)

transcriptional factor;POU-type transcription factor(5460)

"A promoter mutation in a PI regulator affecting the binding of a POU-type transcription factor may be involved in BD and SZ in a subset of patients." (15121481)

phosphorylation;

Q8NEB9

phosphorylation;

Q8NEB9:from_uniprot:525_Phosphoserine

Gene ontology

Gene ontology

GO:0030145 (F) manganese ion binding [Q8NEB9 ];
GO:0048015 (P) phosphoinositide-mediated signaling [Q8NEB9 ];
GO:0046854 (P) phosphoinositide phosphorylation [Q8NEB9 ];
GO:0016303 (F) 1-phosphatidylinositol-3-kinase activity [Q8NEB9 ];
GO:0005515 (F) protein binding [Q8NEB9 ];
GO:0005942 (C) phosphoinositide 3-kinase complex [Q8NEB9 ];
GO:0005524 (F) ATP binding [Q8NEB9 ];

Links

SwissProt

Q8NEB9

Entrez Gene

5289

HPRD

04009



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  Last Modified: 2009-03-24  
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