Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

Official Name

Name from literature

Pathway from literature

Organisms

()

Rate-limiting Description

"." ()

Regulatory Information

Regulatory type

Detail

key enzyme;

"of glutathione levels was accompanied by a dose-dependent decrease in the activity of glutathione reductase (GR), a key enzyme for the regeneration of GSH from GSSG." (11516525)

phosphorylation;

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." (15592455)

transcriptional level;

"In the current study, we investigated the effect of ketoconazole and other azole-derived drugs, miconazole and fluconazole, on the transcriptional activity of the human GR.#The GR-alpha mRNA expression was negatively correlated with the TNF-alpha expression (P < 0.01). " (16608920#16711000)

post translational modification;

"These isoforms display diverse cytoplasm-to-nucleus trafficking patterns and distinct transcription activities. In addition, this new information predicts that each hGR protein can be subjected to a variety of post-translational modifications, such as hosphorylation, sumoylation and ubiquitination. " (17070034)

phosphorylation;

P00390

phosphorylation;

P00390:from_uniprot:65_Phosphotyrosine

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  Last Modified: 2009-03-24  
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