Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

3.1.6.2

Official Name

steryl-sulfatase

Name from literature

sulfatase

Pathway from literature

estrogen synthesis (the sulfatase was the rate-limiting enzyme in estrogen synthesis yet in vitro studies found that it was the aromatase)

Pathway from KEGG

Lipid Metabolism; Androgen and estrogen metabolism; map00150

Organisms

Human (9606)

Genome localization

Xp22.32[412 ],

Comments

Also acts on some related steryl sulfates.

Rate-limiting Description

"The sulfatase was found to be rate limiting at concentrations of DS below 2 microM and the aromatase was found to be rate limiting at higher concentrations." (6233132)

Regulatory Information

Regulatory type

Detail

key enzyme;

"Steroid sulphatase is a key enzyme in the biosynthesis of bioactive estrogens and androgens from highly abundant inactive circulating sulphated steroid precursors." (15696548)

others;

"Corticotrophin-releasing hormone (CRH) increased whereas alpha-helical CRH decreased the mRNA levels of STS, CYP19A1, and HSD17B1, the key enzymes for estrogen synthesis." (16467490)

transcriptional level;

"Tissue-specific transcriptional initiation and activity of steroid sulfatase complementing dehydroepiandrosterone sulfate uptake and intracrine steroid activations in human adipose tissue." (16837617#17596930)

Gene ontology

Gene ontology

GO:0008544 (P) epidermis development [P08842 ];
GO:0005886 (C) plasma membrane [P08842 ];
GO:0005768 (C) endosome [P08842 ];
GO:0006706 (P) steroid catabolic process [P08842 ];
GO:0005794 (C) Golgi apparatus [P08842 ];
GO:0005789 (C) endoplasmic reticulum membrane [P08842 ];
GO:0005509 (F) calcium ion binding [P08842 ];
GO:0007565 (P) female pregnancy [P08842 ];
GO:0016021 (C) integral to membrane [P08842 ];
GO:0005792 (C) microsome [P08842 ];
GO:0004773 (F) steryl-sulfatase activity [P08842 ];
GO:0005764 (C) lysosome [P08842 ];

Subcellular localization

Localization

endoplasmic reticulum [P08842 ];

Disease relevance

Disease

Defects in STS are the cause of ichthyosis X-linked (IXL) [MIM:308100]. Ichthyosis X-linked is a keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks [P08842 ];

Links

SwissProt

P08842

Entrez Gene

412

HPRD

02389



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  Last Modified: 2009-03-24  
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