Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.1.1.37

Official Name

malate dehydrogenase

Name from literature

malate dehydrogenase

Pathway from literature

the NADH shuttle that produces ATP in glucose metabolism

Pathway from KEGG

Carbohydrate Metabolism; Pyruvate metabolism; map00620

Energy Metabolism; Reductive carboxylate cycle (CO2 fixation); map00720

Carbohydrate Metabolism; Glyoxylate and dicarboxylate metabolism; map00630

Carbohydrate Metabolism; Citrate cycle (TCA cycle); map00020

Energy Metabolism; Carbon fixation; map00710

Organisms

Human (9606)

Genome localization

2p13.3[4190 ], 7cen-q22[4191 ],

Comments

Also oxidizes some other 2-hydroxydicarboxylic acids.

Rate-limiting Description

"The normal activity of glucose-6-phosphate dehydrogenase and malate dehydrogenase (decarboxylating) (NADP), which supply NADPH for the reduction of acetyl-CoA to fatty acids, would suggest that the change in lipogenesis is of moderate degree, thereb) affecting only the most rate-limiting enzyme, ATP citrate-lyase." (131232)

Regulatory Information

Regulatory type

Detail

regulatory enzyme;

"Human mitochondrial malic enzyme is a regulatory enzyme with ATP as an inhibitor." (15182181)

phosphorylation;

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." (15592455)

allosteric;

"Human mitochondrial NAD(P)+-dependent malate dehydrogenase (decarboxylating) (malic enzyme) can be specifically and allosterically activated by fumarate." (15989682#16757477)

transcriptional factor;

"Only 33% of the functional variants were found in known consensus transcription factor binding sequences or motifs, which suggests that either there are many unknown transcription factor binding motifs or other, unknown mechanisms are involved. The genes with functional polymorphisms that are reported here for the first time include AGTRL2, CAT, CHRNA5, CTSG, CYP2D6, DLD, ERCC1, GABRA1, GABRP, HNRPH3, HIP1, IGKV1-9, KCNJ15, KCNK6, KLK1, MSMB, MYOC, NPY2R, NOTCH4, ORM2, PEDF, PTPRCAP, ST16 (IL24), SULT1A1, and TSHR." (16086313)

inhibitor;

"Human mitochondrial NAD(P)+-dependent malic enzyme is inhibited by ATP." (16171388)

phosphorylation;

P40925

phosphorylation;

P40926

phosphorylation;

P40925:from_uniprot:210_Phosphotyrosine

phosphorylation;

P40926:from_uniprot:56_Phosphotyrosine

Gene ontology

Gene ontology

GO:0004470 (F) malic enzyme activity [P40925 ];
GO:0006096 (P) glycolysis [P40925, Q6FHZ0, Q75MT9, P40926, Q0QF37 ];
GO:0006108 (P) malate metabolic process [P40925, Q6FHZ0, Q75MT9, P40926, Q0QF37 ];
GO:0005829 (C) cytosol [P40925 ];
GO:0006099 (P) tricarboxylic acid cycle [P40925, Q6FHZ0, Q75MT9, P40926, Q0QF37 ];
GO:0005759 (C) mitochondrial matrix [P40926 ];
GO:0005488 (F) binding [P40925, Q6FHZ0, Q75MT9, P40926, Q0QF37 ];
GO:0030060 (F) L-malate dehydrogenase activity [P40925, Q6FHZ0, Q75MT9, P40926, Q0QF37 ];
GO:0055114 (P) oxidation reduction [P40925, Q6FHZ0, Q75MT9, P40926, Q0QF37 ];

Subcellular localization

Localization

mitochondrion [P40926 ];

cytoplasm [P40925 ];

Links

SwissProt

P40925; P40926; Q0QF37; Q6FHZ0; Q75MT9

Entrez Gene

4190; 4191

HPRD

01099; 01100



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min