Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.1.1.22

Official Name

UDP-glucose 6-dehydrogenase

Name from literature

uridine diphosphoglucose dehydrogenase

Pathway from literature

synthesis of HA

Pathway from KEGG

Carbohydrate Metabolism; Ascorbate and aldarate metabolism; map00053

Carbohydrate Metabolism; Starch and sucrose metabolism; map00500

Carbohydrate Metabolism; Pentose and glucuronate interconversions; map00040

Carbohydrate Metabolism; Nucleotide sugars metabolism; map00520

Organisms

Human (9606)

Genome localization

4p15.1[7358 ],

Comments

Also acts on UDP-2-deoxyglucose.

Rate-limiting Description

"Uridine diphosphoglucose dehydrogenase (UDPGD) activity is the irreversible, rate-limiting step in the production of UDP-glucuronate, an essential monosaccharide in the synthesis of HA." (8471533)

Regulatory Information

Upstream transcription factor

6667

Regulatory type

Detail

transcriptional factor;Sp1(6667)

"Analysis of human UDP-glucose dehydrogenase gene promoter: identification of an Sp1 binding site crucial for the expression of the large transcript." (16002992#16495656)

key enzyme;

"To investigate the mechanisms by which cytokines and 17beta-oestradiol (17beta-E2) modulate gene expression and activity of uridine diphosphoglucose dehydrogenase (UGDH), a key enzyme of GAG synthesis in articular chondrocytes." (18238796)

transcriptional level;

"UGDH core promoter has a role in up- and down-regulation of UGDH after TGF-beta stimulation and in hypoxic conditions" (12682078)

transcriptional level;

"Our results indicate that the region from nucleotide position -486 to -632 relative to the start of the small transcript contains positive regulatory elements that contribute to gene expression." (16002992)

transcriptional level;

"report the presence of an inhibitory cis-element in the distal region of the UGDH promoter that interacts with putative transcriptional repressors for the negative regulation of the UGDH gene" (16495656)

phosphorylation;

O60701

phosphorylation;

O60701:from_uniprot:473_Phosphotyrosine

Gene ontology

Gene ontology

GO:0006065 (P) UDP-glucuronate biosynthetic process [O60701 ];
GO:0003979 (F) UDP-glucose 6-dehydrogenase activity [O60701 ];
GO:0009055 (F) electron carrier activity [O60701 ];
GO:0051287 (F) NAD binding [O60701 ];
GO:0006024 (P) glycosaminoglycan biosynthetic process [O60701 ];
GO:0055114 (P) oxidation reduction [O60701 ];
GO:0006011 (P) UDP-glucose metabolic process [O60701 ];

Links

SwissProt

O60701

Entrez Gene

7358

HPRD

04535



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min