|
||||
|
||||
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases |
Basic Information |
|
---|---|
Enzyme Number | 1.14.99.7 |
Official Name | squalene monooxygenase |
Name from literature | squalene epoxidase |
Pathway from literature | sterol biosynthesis/cholesterol biogenesis |
Pathway from KEGG |
Biosynthesis of Secondary Metabolites; Terpenoid biosynthesis; map00900 |
Lipid Metabolism; Biosynthesis of steroids; map00100 | |
Organisms | Human (9606) |
Genome localization | 8q24.1[6713 ], |
Comments | A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7 lanosterol synthase, was formerly known as squalene oxidocyclase. |
Rate-limiting Description | "Squalene epoxidase (EC 1.14.99.7) catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway." (9286711) |
Regulatory Information |
|
Upstream transcription factor | |
Regulatory type | Detail |
key enzyme; | "The cDNA for human squalene monooxygenase, a key enzyme in the committed pathway for cholesterol biosynthesis, was amplified from a human liver cDNA library and cloned, and the protein was expressed in Escherichia coli and purified." (10666321) |
transcriptional factor;"SREBP-2(6721),NF-Y(4800,4801)" | "SREBP-2 and NF-Y are involved in the transcriptional regulation of squalene epoxidase." (12083769) |
Gene ontology |
|
Gene ontology |
GO:0050660 (F) FAD binding [Q14534 ]; |
Subcellular localization |
|
Localization | |
Links |
|
SwissProt | |
Entrez Gene | |
HPRD |
Copyright 2009, Center for Bioinformatics | |||
Last Modified: 2009-03-24 | |||
Design by Zhao Min |