Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.14.99.7

Official Name

squalene monooxygenase

Name from literature

squalene epoxidase

Pathway from literature

sterol biosynthesis/cholesterol biogenesis

Pathway from KEGG

Biosynthesis of Secondary Metabolites; Terpenoid biosynthesis; map00900

Lipid Metabolism; Biosynthesis of steroids; map00100

Organisms

Human (9606)

Genome localization

8q24.1[6713 ],

Comments

A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7 lanosterol synthase, was formerly known as squalene oxidocyclase.

Rate-limiting Description

"Squalene epoxidase (EC 1.14.99.7) catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway." (9286711)

Regulatory Information

Upstream transcription factor

6721

Regulatory type

Detail

key enzyme;

"The cDNA for human squalene monooxygenase, a key enzyme in the committed pathway for cholesterol biosynthesis, was amplified from a human liver cDNA library and cloned, and the protein was expressed in Escherichia coli and purified." (10666321)

transcriptional factor;"SREBP-2(6721),NF-Y(4800,4801)"

"SREBP-2 and NF-Y are involved in the transcriptional regulation of squalene epoxidase." (12083769)

Gene ontology

Gene ontology

GO:0050660 (F) FAD binding [Q14534 ];
GO:0046246 (P) terpene biosynthetic process [Q14534 ];
GO:0016021 (C) integral to membrane [Q14534 ];
GO:0005792 (C) microsome [Q14534 ];
GO:0016126 (P) sterol biosynthetic process [Q14534 ];
GO:0004506 (F) squalene monooxygenase activity [Q14534 ];
GO:0055114 (P) oxidation reduction [Q14534 ];
GO:0005789 (C) endoplasmic reticulum membrane [Q14534 ];

Subcellular localization

Localization

endoplasmic reticulum [Q14534 ];

microsome [Q14534 ];

Links

SwissProt

Q14534

Entrez Gene

6713

HPRD

11802



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  Last Modified: 2009-03-24  
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