1.14.99.7

squalene monooxygenase

squalene epoxidase

sterol biosynthesis/cholesterol biogenesis

Human (9606)

8q24.1[6713 ],

A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7 lanosterol synthase, was formerly known as squalene oxidocyclase.

"Squalene epoxidase (EC 1.14.99.7) catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway." (9286711)

6721

key enzyme;

"The cDNA for human squalene monooxygenase, a key enzyme in the committed pathway for cholesterol biosynthesis, was amplified from a human liver cDNA library and cloned, and the protein was expressed in Escherichia coli and purified." (10666321)

transcriptional factor;"SREBP-2(6721),NF-Y(4800,4801)"

"SREBP-2 and NF-Y are involved in the transcriptional regulation of squalene epoxidase." (12083769)

GO:0050660 (F) FAD binding [Q14534 ];
GO:0046246 (P) terpene biosynthetic process [Q14534 ];
GO:0016021 (C) integral to membrane [Q14534 ];
GO:0005792 (C) microsome [Q14534 ];
GO:0016126 (P) sterol biosynthetic process [Q14534 ];
GO:0004506 (F) squalene monooxygenase activity [Q14534 ];
GO:0055114 (P) oxidation reduction [Q14534 ];
GO:0005789 (C) endoplasmic reticulum membrane [Q14534 ];

endoplasmic reticulum [Q14534 ];

microsome [Q14534 ];

Q14534

6713

11802