Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

3.4.14.5

Official Name

dipeptidyl-peptidase IV

Name from literature

dipeptidyl peptidase

Pathway from literature

the hydrolysis of the alanine substrates

Organisms

Human (9606)

Genome localization

15q22[54878 ], 2q24.3[1803 ], 19p13.3[91039 ],

Comments

A homodimer. An integral protein of the plasma membrane of lymphocytes and other mammalian cells, in peptidase family S9 (prolyl oligopeptidase family). The reaction is similar to that of the unrelated EC 3.4.14.11 Xaa-Pro dipeptidyl-peptidase of lactococci

Rate-limiting Description

"Moreover, as estimated from the residual peptide structure and confirmed by exogenous peptidase supplementation, dipeptidyl peptidase IV and dipeptidyl carboxypeptidase I were identified as the rate-limiting enzymes in the digestive breakdown of these peptides." (12223360)

Regulatory Information

Upstream transcription factor

6928;6927

Regulatory type

Detail

phosphorylation;

"Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line." (14729942)

transcriptional factor;"HNF1alpha(6927),HNF1beta(6928)"

"both wild HNF-1alpha and wild HNF-1beta have a stimulatory effect on DPP-IV gene expression, but that mutant hepatocyte nuclear factors (HNF)-1alpha and mutant HNF-1beta attenuate the stimulatory effect" (16781669)

transcriptional factor;hepatocyte nuclear factor 1 alpha(6927)

"Regulation of the gene for human dipeptidyl peptidase IV by hepatocyte nuclear factor 1 alpha." (9931303)

others;

"adult T-cell leukemia cells down-regulate CD26 antigens by means of epigenetic machinery; faintly detected transcripts of the gene were aberrantly methylated at the CpG islands within the promoter region in parallel with the advancement of ATL" (15540901)

phosphorylation;

P27487

phosphorylation;

Q6V1X1

phosphorylation;

Q6V1X1:from_uniprot:331_Phosphotyrosine

phosphorylation;

Q6V1X1:from_uniprot:334_Phosphothreonine

Gene ontology

Gene ontology

GO:0004177 (F) aminopeptidase activity [P27487, Q6V1X1, Q86TI2 ];
GO:0016020 (C) membrane [Q6V1X1, Q86TI2 ];
GO:0006955 (P) immune response [Q6V1X1 ];
GO:0006508 (P) proteolysis [P27487, Q6V1X1, Q86TI2 ];
GO:0001666 (P) response to hypoxia [P27487 ];
GO:0042803 (F) protein homodimerization activity [P27487 ];
GO:0005737 (C) cytoplasm [Q6V1X1, Q86TI2 ];
GO:0042110 (P) T cell activation [P27487 ];
GO:0004252 (F) serine-type endopeptidase activity [P27487, Q6V1X1, Q86TI2 ];
GO:0009986 (C) cell surface [P27487 ];
GO:0005576 (C) extracellular region [P27487 ];
GO:0016021 (C) integral to membrane [P27487 ];
GO:0005634 (C) nucleus [Q6V1X1 ];
GO:0033632 (P) regulation of cell-cell adhesion mediated b... [P27487 ];
GO:0008239 (F) dipeptidyl-peptidase activity [P27487, Q6V1X1 ];

Tissue expression

Tissue From HPRD

Serum [02187 ];
Colon [07076, 07001, 02187 ];
Jejunum [02187 ];
Ubiquitous [07076, 07001 ];
Fetus [07001 ];
Testis [07076, 07001 ];
Thymocyte [02187 ];
Brain [07076, 07001, 02187 ];
Spleen [07076, 07001, 02187 ];
Small intestine [07076, 07001 ];
Bronchus [02187 ];
Cytotrophoblast [02187 ];
Endometrium [02187 ];
Heart [07076, 07001, 02187 ];
Lymphocyte [02187 ];
Th(1) cell [02187 ];
Natural killer cell [02187 ];
Duodenum [02187 ];
Thymus [07076, 07001 ];
Uterus [07001 ];
Intestine [07076 ];
Leukocyte [07076, 07001 ];
Liver [07076, 07001, 02187 ];
Skeletal muscle [07076, 07001, 02187 ];
Muscle [07076 ];
Keratinocyte [02187 ];
Prostate [07076, 07001 ];
Kidney [07076, 07001, 02187 ];
Th(2) cell [02187 ];
Lung [07076, 07001, 02187 ];
Ovary [07076 ];
Pancreas [07076, 07001, 02187 ];
Ileum [02187 ];
Plasma [02187 ];
Skin [02187 ];
Placenta [07076, 07001, 02187 ];
Semen [02187 ];

Tissue specificity

Ubiquitously expressed, with highest levels in liver, heart and muscle, and lowest levels in brain [Q86TI2 ];

Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain [Q6V1X1 ];

Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon [P27487 ];

Subcellular localization

Localization

extracellular [P27487 ];

cell membrane [P27487 ];

cytoplasm [Q6V1X1, Q86TI2 ];

Links

SwissProt

P27487; Q6V1X1; Q86TI2

Entrez Gene

1803; 54878; 91039

HPRD

07076; 07001; 02187



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min