Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.1.1.105

Official Name

retinol dehydrogenase

Name from literature

cis retinol dehydrogenase

Pathway from literature

biosynthesis of 9-cis-retinoic acid

Organisms

Human (9606)

Rate-limiting Description

"The 11-cis retinol dehydrogenase (11-cis-RoDH) enzyme catalyzes the oxidation of cis-retinols to their respective retinals, a rate limiting step in the formation of retinoic acids." (11377978)

Regulatory Information

Upstream transcription factor

5468

Regulatory type

Detail

key enzyme;

"Biosynthesis of 11-cis-retinal is required to maintain vision. A key enzyme catalyzing the oxidation of 11-cis-retinol is 11-cis-retinol dehydrogenase (11-cis-RDH), which is encoded by the RDH5 gene." (11153648)

transcriptional factor;PPARgamma(5468)

"Here we demonstrate that PPARgamma, turns on retinoic acid synthesis by inducing the expression of retinol and retinal metabolizing enzymes such as retinol dehydrogenase 10 and retinaldehyde dehydrogenase type 2 (RALDH2)." (16982809)

inhibitor;

"ethanol,Apo-CRBP," (8810827)

Gene ontology

Gene ontology

GO:0005783 (C) endoplasmic reticulum [O14756 ];
GO:0016020 (C) membrane [Q92781 ];
GO:0007601 (P) visual perception [Q92781 ];
GO:0050896 (P) response to stimulus [Q92781 ];
GO:0031901 (C) early endosome membrane [O14756 ];
GO:0004303 (F) estradiol 17-beta-dehydrogenase activity [O14756 ];
GO:0009055 (F) electron carrier activity [O14756 ];
GO:0005792 (C) microsome [O14756 ];
GO:0006702 (P) androgen biosynthetic process [O14756 ];
GO:0006710 (P) androgen catabolic process [O14756 ];
GO:0050327 (F) testosterone 17-beta-dehydrogenase activity [O14756 ];
GO:0004745 (F) retinol dehydrogenase activity [Q92781, O14756 ];
GO:0005488 (F) binding [Q92781, O14756 ];
GO:0055114 (P) oxidation reduction [Q92781, O14756 ];

Tissue expression

Tissue From HPRD

Thymus [03370 ];
Colon [03370 ];
Nervous system [03370 ];
Kidney [03370 ];
Uterus [03370 ];
Mammary gland [03370 ];
Heart [03370 ];
Intestine [03370 ];
Testis [03370 ];
Liver [03370 ];
Retina [03370 ];
Spleen [03370 ];

Tissue specificity

Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain [O14756 ];

Abundant in the retinal pigment epithelium [Q92781 ];

Subcellular localization

Localization

endosome [O14756 ];

cell membrane [Q92781, O14756 ];

microsome [O14756 ];

Disease relevance

Disease

Defects in RDH5 are a cause of fundus albipunctatus (FA) [MIM:136880]. FA is a rare form of stationary night blindness characterized by a delay in the regeneration of cone and rod photopigments [Q92781 ];

Links

SwissProt

O14756; Q92781

Entrez Gene

5959; 8630

HPRD

03370



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min