Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.7.1.32

Official Name

choline kinase

Name from literature

choline kinase

Pathway from literature

biosynthesis of phosphatidylcholine

Pathway from KEGG

Amino Acid Metabolism; Glycine, serine and threonine metabolism; map00260

Lipid Metabolism; Glycerophospholipid metabolism; map00564

Organisms

Human (9606)

Genome localization

11q13.2[1119 ], 22q13.33[1120 ],

Comments

Ethanolamine and its methyl and ethyl derivatives can also act as acceptors.

Rate-limiting Description

"Perfusion with the phospholipid precursors ethanolamine or choline (2 mM) indicates that the cytidylyltransferase enzymes are rate limiting for both pathways." (2153442)

Regulatory Information

Upstream transcription factor

5978

Regulatory type

Detail

phosphorylation;

"Here we have investigated the mechanism of regulation of choline kinase by Ras proteins and found no direct link between PLD and choline kinase activation. We provide evidence that Ras proteins regulate the activity of choline kinase through its direct effectors Ral-GDS and PI3K, while the Raf pathways seems to be not relevant in this process. " (11840339)

signal pathway;

"The Ras effectors serine/threonine kinase (Raf-1), the Ral-GDP dissociation stimulator (Ral-GDS) and the phosphatidylinositol 3-kinase (PI3K) are involved in the activation of ChoK during tumorigenesis." (16719778)

transcriptional factor;REST(5978)

"This sequence census method was then used to map in vivo binding of the neuron-restrictive silencer factor (NRSF; also known as REST, for repressor element-1 silencing transcription factor) to 1946 locations in the human genome." (17540862)

phosphorylation;

Q9Y259:from_uniprot:39_Phosphoserine

phosphorylation;

Q9Y259:from_uniprot:42_Phosphoserine

Gene ontology

Gene ontology

GO:0004305 (F) ethanolamine kinase activity [Q9Y259 ];
GO:0045735 (F) nutrient reservoir activity [P35790 ];
GO:0004871 (F) signal transducer activity [P35790 ];
GO:0006629 (P) lipid metabolic process [P35790 ];
GO:0004103 (F) choline kinase activity [P35790, Q9Y259 ];
GO:0006869 (P) lipid transport [P35790 ];
GO:0005737 (C) cytoplasm [P35790 ];

Subcellular localization

Localization

cytoplasm [P35790 ];

Links

SwissProt

P35790; Q9Y259

Entrez Gene

1119; 1120

HPRD

07631; 00327



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min