Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.2.1.36

Official Name

retinal dehydrogenase

Name from literature

retinal dehydrogenase

Pathway from literature

the metabolism of retinal to retinoic acid

Pathway from KEGG

Metabolism of Cofactors and Vitamins; Retinol metabolism; map00830

Organisms

Human (9606)

Genome localization

15q22.1[8854 ], 9q21.13[216 ],

Comments

A metalloflavoprotein (FAD). Acts on both the 11-trans- and 13-cis-forms of retinal.

Rate-limiting Description

"The tissue RA level is maintained through a cascade of metabolic reactions where retinal dehydrogenases (RALDHs) catalyze the terminal reaction of RA biosynthesis from retinal, a rate-limiting step." (16763553)

Regulatory Information

Regulatory type

Detail

key enzyme;

"To evaluate retinol levels in patients with or without HAART and to assess the effect of antiretroviral agents on retinal dehydrogenase (RALDH), a key enzyme involved in retinoic acid synthesis." (11600826)

transcriptional level;

"The promoter region of a gene can influence gene expression, the ALDH1A1 promoter regions were studied to identify polymorphism, to assess their functional significance, and to determine whether they were associated with a risk for developing alcoholism." (14506398)

phosphorylation;

O94788

phosphorylation;

P00352

phosphorylation;

O94788:from_uniprot:122_Phosphothreonine

Gene ontology

Gene ontology

GO:0005099 (F) Ras GTPase activator activity [P00352 ];
GO:0005497 (F) androgen binding [P00352 ];
GO:0006081 (P) cellular aldehyde metabolic process [P00352 ];
GO:0005829 (C) cytosol [P00352 ];
GO:0005737 (C) cytoplasm [O94788 ];
GO:0001758 (F) retinal dehydrogenase activity [P00352, O94788 ];
GO:0009055 (F) electron carrier activity [O94788 ];
GO:0004029 (F) aldehyde dehydrogenase (NAD) activity [P00352 ];
GO:0005634 (C) nucleus [P00352 ];
GO:0004028 (F) 3-chloroallyl aldehyde dehydrogenase activity [O94788 ];
GO:0055114 (P) oxidation reduction [P00352, O94788 ];

Subcellular localization

Localization

cytoplasm [P00352, O94788 ];

Links

SwissProt

O94788; P00352

Entrez Gene

216; 8854

HPRD

00001; 04733



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  Last Modified: 2009-03-24  
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