|
||||
|
||||
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases |
Basic Information |
|
---|---|
Enzyme Number | 1.2.1.36 |
Official Name | retinal dehydrogenase |
Name from literature | retinal dehydrogenase |
Pathway from literature | the metabolism of retinal to retinoic acid |
Pathway from KEGG |
Metabolism of Cofactors and Vitamins; Retinol metabolism; map00830 |
Organisms | Human (9606) |
Genome localization | |
Comments | A metalloflavoprotein (FAD). Acts on both the 11-trans- and 13-cis-forms of retinal. |
Rate-limiting Description | "The tissue RA level is maintained through a cascade of metabolic reactions where retinal dehydrogenases (RALDHs) catalyze the terminal reaction of RA biosynthesis from retinal, a rate-limiting step." (16763553) |
Regulatory Information |
|
Regulatory type | Detail |
key enzyme; | "To evaluate retinol levels in patients with or without HAART and to assess the effect of antiretroviral agents on retinal dehydrogenase (RALDH), a key enzyme involved in retinoic acid synthesis." (11600826) |
transcriptional level; | "The promoter region of a gene can influence gene expression, the ALDH1A1 promoter regions were studied to identify polymorphism, to assess their functional significance, and to determine whether they were associated with a risk for developing alcoholism." (14506398) |
phosphorylation; | O94788 |
phosphorylation; | P00352 |
phosphorylation; | O94788:from_uniprot:122_Phosphothreonine |
Gene ontology |
|
Gene ontology |
GO:0005099 (F) Ras GTPase activator activity [P00352 ]; |
Subcellular localization |
|
Localization | |
Links |
|
SwissProt | |
Entrez Gene | |
HPRD |
Copyright 2009, Center for Bioinformatics | |||
Last Modified: 2009-03-24 | |||
Design by Zhao Min |