1.2.1.36

retinal dehydrogenase

retinal dehydrogenase

the metabolism of retinal to retinoic acid

Human (9606)

15q22.1[8854 ], 9q21.13[216 ],

A metalloflavoprotein (FAD). Acts on both the 11-trans- and 13-cis-forms of retinal.

"The tissue RA level is maintained through a cascade of metabolic reactions where retinal dehydrogenases (RALDHs) catalyze the terminal reaction of RA biosynthesis from retinal, a rate-limiting step." (16763553)

key enzyme;

"To evaluate retinol levels in patients with or without HAART and to assess the effect of antiretroviral agents on retinal dehydrogenase (RALDH), a key enzyme involved in retinoic acid synthesis." (11600826)

transcriptional level;

"The promoter region of a gene can influence gene expression, the ALDH1A1 promoter regions were studied to identify polymorphism, to assess their functional significance, and to determine whether they were associated with a risk for developing alcoholism." (14506398)

phosphorylation;

phosphorylation;

phosphorylation;

GO:0005099 (F) Ras GTPase activator activity [P00352 ];
GO:0005497 (F) androgen binding [P00352 ];
GO:0006081 (P) cellular aldehyde metabolic process [P00352 ];
GO:0005829 (C) cytosol [P00352 ];
GO:0005737 (C) cytoplasm [O94788 ];
GO:0001758 (F) retinal dehydrogenase activity [P00352, O94788 ];
GO:0009055 (F) electron carrier activity [O94788 ];
GO:0004029 (F) aldehyde dehydrogenase (NAD) activity [P00352 ];
GO:0005634 (C) nucleus [P00352 ];
GO:0004028 (F) 3-chloroallyl aldehyde dehydrogenase activity [O94788 ];
GO:0055114 (P) oxidation reduction [P00352, O94788 ];

cytoplasm [P00352, O94788 ];

O94788; P00352

216; 8854

00001; 04733