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Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases |
Basic Information |
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Enzyme Number | 2.7.1.33 |
Official Name | pantothenate kinase |
Name from literature | pantothenate kinase |
Pathway from literature | coenzyme A ( CoA ) biosynthetic pathway |
Pathway from KEGG |
Metabolism of Cofactors and Vitamins; Pantothenate and CoA biosynthesis; map00770 |
Organisms | Human (9606) |
Genome localization | 20p13[80025 ], 1p36.32[55229 ], 5q34[79646 ], 10q23.31[53354 ], |
Rate-limiting Description | "Pantothenate kinase (PanK) is thought to catalyze the first rate-limiting step in CoA biosynthesis." (14523052) |
Regulatory Information |
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Upstream transcription factor | |
Regulatory type | Detail |
transcriptional factor;PPARalpha transcription factor(5465) | "PPARalpha transcription factor as a major factor governing hepatic CoA levels by specific modulation of PANK1alpha gene expression" (14523052) |
phosphorylation;PanK4 | "PanK4 interacts with Pkm2 and thereby may modulate the glucose metabolism through regulating the activity of Pkm2." (16132722) |
phosphorylation; | Q9BZ23 |
phosphorylation; | Q9NVE7 |
phosphorylation; | Q9BZ23:from_uniprot:189_Phosphoserine |
Gene ontology |
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Gene ontology |
GO:0005739 (C) mitochondrion [Q9BZ23 ]; |
Tissue expression |
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Tissue From HPRD |
Kidney [07312, 07549, 05857, 07313 ]; |
Tissue specificity |
Highly expressed in the liver [Q9H999 ]; |
Subcellular localization |
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Localization |
mitochondrion [Q9BZ23 ]; |
Disease relevance |
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Disease |
Defects in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP) [MIM:607236]. HARP is a rare syndrome with many clinical similarities to PKAN [Q9BZ23 ]; |
Links |
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SwissProt | |
Entrez Gene | |
HPRD |
Copyright 2009, Center for Bioinformatics | |||
Last Modified: 2009-03-24 | |||
Design by Zhao Min |