Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.7.1.20

Official Name

adenosine kinase

Name from literature

adenosine kinase

Pathway from literature

adenosine uptake and metabolism

Pathway from KEGG

Nucleotide Metabolism; Purine metabolism; map00230

Organisms

Human (9606)

Genome localization

10q22|10q11-q24[132 ],

Comments

2-Aminoadenosine can also act as acceptor.

Rate-limiting Description

"Relative to normal brain the tumors had significantly lower ATP and GTP levels, essentially normal pool sizes of purine nucleosides and bases, unchanged activities of the salvage enzymes hypoxanthine-guanine phosphoribosyltransferase, adenine phosphoribosyltransferase, and adenosine kinase (659, 456, and 98 nmol/h/mg protein, respectively) and 4-fold higher activities of IMP dehydrogenase (11.6 nmol/h/mg protein); the latter is the rate limiting enzyme for guanylate de novo synthesis." (2154328)

"The time course of F-AR uptake suggested that the rate-limiting step was not membrane transport but the intracellular phosphorylation by adenosine kinase." (8184939)

"Adenosine is a potent modulator of immune function, and adenosine kinase (AK), a rate-limiting enzyme for adenosine uptake and metabolism, is a potential mediator of adenosine regulation." (12228764)

Regulatory Information

Upstream transcription factor

3091

Regulatory type

Detail

key enzyme;

"In T. gondii tachyzoites, adenosine is the predominantly salvaged purine nucleoside, and thus adenosine kinase is a key enzyme in the purine salvage pathway of this parasite." (10794412)

signal pathway;adenosine-dependent pathway

"Equilibrative nucleoside transporters (hENT1, hENT2) together with adenosine kinase and 5'-nucleotidase play a crucial role in the regulation of CFTR through an adenosine-dependent pathway in human airway epithelia." (18309031)

transcriptional factor;HIF-1alpha(3091)

"role for HIF-1alpha in transcriptional repression of AK in hypoxia" (18309031)

phosphorylation;

P55263:from_uniprot:77_Phosphotyrosine

Gene ontology

Gene ontology

GO:0000287 (F) magnesium ion binding [P55263 ];
GO:0006166 (P) purine ribonucleoside salvage [P55263 ];
GO:0004001 (F) adenosine kinase activity [P55263 ];
GO:0009156 (P) ribonucleoside monophosphate biosynthetic p... [P55263 ];

Tissue expression

Tissue From HPRD

Kidney [00039 ];
Leukocyte [00039 ];
Heart [00039 ];
Lung [00039 ];
Pancreas [00039 ];
Liver [00039 ];
Skeletal muscle [00039 ];
Placenta [00039 ];
Muscle [00039 ];
Brain [00039 ];
Spleen [00039 ];

Tissue specificity

Widely expressed. Highest level in placenta, liver, muscle and kidney [P55263 ];

Links

SwissProt

P55263

Entrez Gene

132

HPRD

00039



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min