Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.7.7.1

Official Name

nicotinamide-nucleotide adenylyltransferase

Name from literature

NMN adenylyltransferase

Pathway from literature

biosynthesis of NAD

Pathway from KEGG

Metabolism of Cofactors and Vitamins; Nicotinate and nicotinamide metabolism; map00760

Organisms

Human (9606)

Genome localization

1p32-p35[64802 ], 1q25[23057 ], 3q23[349565 ],

Comments

Nicotinate nucleotide can also act as acceptor. See also EC 2.7.7.18 nicotinate-nucleotide adenylyltransferase.

Rate-limiting Description

"BR 5'-monophosphate is then converted to the active metabolite benzamide adenine dinucleotide (BAD) by NMN adenylyltransferase, the rate-limiting enzyme in the biosynthesis of NAD." (11966442)

Regulatory Information

Upstream transcription factor

5978

Regulatory type

Detail

transcriptional factor;REST(5978)

"This sequence census method was then used to map in vivo binding of the neuron-restrictive silencer factor (NRSF; also known as REST, for repressor element-1 silencing transcription factor) to 1946 locations in the human genome." (17540862)

phosphorylation;

"Regulation of poly(ADP-ribose) polymerase 1 activity by the phosphorylation state of the nuclear NAD biosynthetic enzyme NMN adenylyl transferase 1." (17360427)

phosphorylation;

"depending on its state of phosphorylation, NMNAT-1 binds to activated, automodifying PARP-1 and thereby amplifies poly(ADP-ribosyl)ation" (17360427)

phosphorylation;

Q9BZQ4

phosphorylation;

Q9HAN9

phosphorylation;

Q9HAN9:from_uniprot:119_Phosphothreonine

Gene ontology

Gene ontology

GO:0000287 (F) magnesium ion binding [Q9HAN9 ];
GO:0005634 (C) nucleus [Q9HAN9, Q96T66 ];
GO:0009435 (P) NAD biosynthetic process [Q9HAN9, Q9BZQ4, Q96T66 ];
GO:0005515 (F) protein binding [Q9HAN9 ];
GO:0005737 (C) cytoplasm [Q9BZQ4 ];
GO:0000309 (F) nicotinamide-nucleotide adenylyltransferase... [Q9HAN9, Q9BZQ4, Q96T66 ];

Tissue expression

Tissue From HPRD

Thymus [16369 ];
Cerebrum [09786 ];
Hippocampus [16369, 09786 ];
Substantia nigra [16369 ];
Corpus callosum [16369 ];
Occipital lobe [09786 ];
Spinal cord [16369 ];
Putamen [09786 ];
Caudate nucleus [16369, 09786 ];
Testis [09786 ];
Temporal lobe [09786 ];
Liver [16369 ];
Skeletal muscle [16369, 09786 ];
Brain [16369, 09786 ];
Spleen [16370 ];
Kidney [16369, 16370 ];
Thalamus [16369, 09786 ];
Lung [16370 ];
Heart [16369, 09786 ];
Amygdala [16369, 09786 ];
Pancreas [16369, 09786 ];
Cerebellum [09786 ];
Placenta [16369, 09786, 16370 ];
Subthalamic nucleus [16369 ];
Frontal lobe [09786 ];

Tissue specificity

Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Detected at lower levels in heart and skeletal muscle. Detected in pancreas and islets of Langerhans [Q9BZQ4 ];

Widely expressed with highest levels in skeletal muscle, heart, liver and kidney. Widely expressed throughout the brain [Q9HAN9 ];

Subcellular localization

Localization

nucleus [Q9HAN9, Q96T66 ];

cytoplasm [Q9BZQ4 ];

Links

SwissProt

Q96T66; Q9BZQ4; Q9HAN9

Entrez Gene

23057; 349565; 64802

HPRD

16370; 16369; 09786



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min