Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.14.13.99

Official Name

24-hydroxycholesterol 7alpha-hydroxylase

Name from literature

CYP39A1

Pathway from literature

bile acid synthesis

Organisms

Human (9606)

Genome localization

6p21.1-p11.2[51302 ],

Comments

A heme-thiolate protein (P-450) that is found in liver microsomes and in ciliary non-pigmented epithelium [2]. The enzyme is specific for (24R)-cholest-5-ene-3beta,24-diol as substrate.

Rate-limiting Description

"In liver, 7 alpha-hydroxylation of cholesterols, mediated by CYP7A and CYP39A1, is the rate-limiting step of bile acid synthesis and metabolic elimination." (12398993)

Regulatory Information

Upstream transcription factor

4783;8431

Regulatory type

Detail

transcriptional factor;"E4BP4(4783),orphan nuclear receptor small heterodimer partner(8431)"

"Hepatic expression of E4BP4 and the orphan nuclear receptor small heterodimer partner (SHP), both negative regulators of CYP7A1 expression." (18565334)

Gene ontology

Gene ontology

GO:0008396 (F) oxysterol 7-alpha-hydroxylase activity [Q9NYL5 ];
GO:0020037 (F) heme binding [Q9NYL5 ];
GO:0006699 (P) bile acid biosynthetic process [Q9NYL5 ];
GO:0005506 (F) iron ion binding [Q9NYL5 ];
GO:0005789 (C) endoplasmic reticulum membrane [Q9NYL5 ];
GO:0030573 (P) bile acid catabolic process [Q9NYL5 ];
GO:0009055 (F) electron carrier activity [Q9NYL5 ];
GO:0005792 (C) microsome [Q9NYL5 ];
GO:0007586 (P) digestion [Q9NYL5 ];
GO:0055114 (P) oxidation reduction [Q9NYL5 ];
GO:0033782 (F) 24-hydroxycholesterol 7alpha-hydroxylase ac... [Q9NYL5 ];

Tissue expression

Tissue From HPRD

Liver [07067 ];

Tissue specificity

Liver specific [Q9NYL5 ];

Subcellular localization

Localization

endoplasmic reticulum [Q9NYL5 ];

microsome [Q9NYL5 ];

membrane [Q9NYL5 ];

Links

SwissProt

Q9NYL5

Entrez Gene

51302

HPRD

07067



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  Last Modified: 2009-03-24  
  Design by Zhao Min