Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.1.87

Official Name

aralkylamine N-acetyltransferase

Name from literature

arylalkylamine N-acetyltransferase

Pathway from literature

melatonin synthesis

Pathway from KEGG

Amino Acid Metabolism; Tryptophan metabolism; map00380

Organisms

Human (9606)

Genome localization

17q25[15 ],

Comments

Narrow specificity towards 2-arylethylamines, including serotonin (5-hydroxytryptamine), tryptamine, 5-methoxytryptamine and phenylethylamine. This is the penultimate enzyme in the production of melatonin (5-methoxy-N-acetyltryptamine) and controls its synthesis (cf. EC 2.1.1.4, acetylserotonin O-methyltransferase). Differs from EC 2.3.1.5 arylamine N-acetyltransferase.

Rate-limiting Description

"The melatonin rhythm is arguably the best marker for the phase of the endogenous "biological clock." Arylalkylamine N-acetyltransferase (AANAT) is known to catalyze the acetylation of serotonin, a rate-limiting process in melatonin synthesis." (18569588)

Regulatory Information

Upstream transcription factor

7534;5568

Regulatory type

Detail

phosphorylation;PKA(5568)

"PKA phosphorylates serotonin N-acetyltransferase (AANAT; the penultimate and key regulatory enzyme in melatonin biosynthesis pathway) at its N- (Thr31) and C-(Ser205)terminal region. Phosphorylated of AANAT bind to 14-3-3 proteins." (16869299)

regulatory enzyme;

"PKA phosphorylates serotonin N-acetyltransferase (AANAT; the penultimate and key regulatory enzyme in melatonin biosynthesis pathway) at its N- (Thr31) and C-(Ser205)terminal region. Phosphorylated of AANAT bind to 14-3-3 proteins." (16869299)

phosphorylation;

Q16613

transcriptional factor;YWHAZ(7534)

"Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation." (11336675)

transcriptional factor;YWHAZ(7534)

"Cloning and characterization of the epsilon and zeta isoforms of the 14-3-3 proteins." (8024705#11336675#11427721)

Gene ontology

Gene ontology

GO:0004059 (F) aralkylamine N-acetyltransferase activity [Q16613 ];
GO:0007623 (P) circadian rhythm [Q16613 ];
GO:0008152 (P) metabolic process [Q16613 ];

Tissue expression

Tissue From HPRD

Skin [02974 ];
Pineal gland [02974 ];
Retina [02974 ];
Brain [02974 ];
Pituitary gland [02974 ];

Tissue specificity

Highly expressed in pineal gland and retina [Q16613 ];

Links

SwissProt

Q16613

Entrez Gene

15

HPRD

02974



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  Last Modified: 2009-03-24  
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