Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

4.1.1.17

Official Name

ornithine decarboxylase

Name from literature

ornithine decarboxylase

Pathway from literature

polyamine metabolism

Pathway from KEGG

Metabolism of Other Amino Acids; Glutathione metabolism; map00480

Amino Acid Metabolism; Urea cycle and metabolism of amino groups; map00220

Organisms

Human (9606)

Genome localization

2p25[4953 ],

Comments

A pyridoxal-phosphate protein.

Rate-limiting Description

"Another suggestion is that these kinases may also participate in the post-translational regulation of ornithine decarboxylase, the rate-limiting step in the polyamine biosynthetic pathway." (6190690)

"Treatment with alpha-difluoromethylornithine (DFMO), a selective inhibitor of the rate-limiting biosynthetic enzyme ornithine decarboxylase, produced dose-dependent inhibition of the respiratory burst in PMNs that were primed by these agents and subsequently activated by formyl-Met-Leu-Phe (fMLP)." (9368191)

Regulatory Information

Upstream transcription factor

4609

Regulatory type

Detail

regulatory enzyme;

"Ornithine decarboxylase (ODC), a critical regulatory enzyme for polyamine biosynthesis, is strictly regulated in human cells." (12148577)

transcriptional factor;c-Myb(4609)

"Transcriptional regulation of the ornithine decarboxylase gene by c-Myc/Max/Mad network and retinoblastoma protein interacting with c-Myc." (12565711)

phosphorylation;

P11926

phosphorylation;

P11926:from_uniprot:303_Phosphoserine; by CK2

Gene ontology

Gene ontology

GO:0004586 (F) ornithine decarboxylase activity [P11926 ];
GO:0005634 (C) nucleus [P11926 ];
GO:0006596 (P) polyamine biosynthetic process [P11926 ];
GO:0005515 (F) protein binding [P11926 ];

Links

SwissProt

P11926

Entrez Gene

4953

HPRD

01324



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min