Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.1.1.45

Official Name

thymidylate synthase

Name from literature

Thymidylate synthase

Pathway from literature

the synthesis of pyrimidine nucleotides

Pathway from KEGG

Metabolism of Cofactors and Vitamins; One carbon pool by folate; map00670

Nucleotide Metabolism; Pyrimidine metabolism; map00240

Organisms

Human (9606)

Genome localization

18p11.32[7298 ],

Rate-limiting Description

"Thymidylate synthase (TS) catalyses the de novo synthesis of deoxythymidylate and is a key rate-limiting enzyme of DNA synthesis." (12457437)

"Thymidylate synthase (TS), a key one-carbon metabolizing gene, encodes an enzyme that converts dUMP to dTMP, the rate-limiting nucleotide in DNA synthesis." (15598787)

"Thymidylate synthase (TS) is the rate-limiting enzyme in the synthesis of pyrimidine nucleotides, required for DNA synthesis, and is also a critical target for fluoropyrimidines, which are widely used in the treatment of gastrointestinal tumours." (16077970)

"Thymidylate synthase (TS), the target enzyme of FUra, and dihydropyrimidine dehydrogenase (DPD), the rate-limiting catabolic enzyme of pyrimidines, have both been reported to be predictors of the response to FUra-based chemotherapies." (14689231)

"AIM: Thymidylate synthase (TS) is a rate-limiting enzyme in the DNA synthetic pathway, and represents a cellular target of antimetabolite drug 5-fluorouracil." (16617381)

Regulatory Information

Upstream transcription factor

1869;1874

Regulatory type

Detail

inhibitor;

"thymidylate synthase is inhibited by trifluorothymidine in human tumor cells" (15571283)

interact with TF;E2F1(1869)

"Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis." (11799066)

interact with TF;E2F4(1874)

"Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis." (11799066)

Gene ontology

Gene ontology

GO:0006281 (P) DNA repair [P04818 ];
GO:0006231 (P) dTMP biosynthetic process [Q53Y97, A8K9A5, Q53FB7, P04818 ];
GO:0048015 (P) phosphoinositide-mediated signaling [P04818 ];
GO:0006260 (P) DNA replication [P04818 ];
GO:0004799 (F) thymidylate synthase activity [Q53Y97, A8K9A5, Q53FB7, P04818 ];
GO:0005829 (C) cytosol [P04818 ];

Links

SwissProt

A8K9A5; P04818; Q53FB7; Q53Y97

Entrez Gene

7298

HPRD

01774



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  Last Modified: 2009-03-24  
  Design by Zhao Min