Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

3.1.3.4

Official Name

phosphatidate phosphatase

Name from literature

phosphatidate phosphohydrolase

Pathway from literature

triacylglycerol(TG) synthesis/the de novo synthesis of lipids and cholesterol

Pathway from KEGG

Lipid Metabolism; Sphingolipid metabolism; map00600

Lipid Metabolism; Glycerolipid metabolism; map00561

Lipid Metabolism; Ether lipid metabolism; map00565

Lipid Metabolism; Glycerophospholipid metabolism; map00564

Organisms

Human (9606)

Genome localization

5q11[8611 ], 19p13[8612 ], 1pter-p22.1[8613 ],

Rate-limiting Description

"According to current concepts, soluble phosphatidic-acid phosphatase, converting phosphatidic acid into a diglyceride, is a rate-limiting enzyme in the hepatic biosynthesis of triglycerides." (6088251)

Regulatory Information

Upstream transcription factor

7161

Regulatory type

Detail

phosphorylation;

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." (17081983)

transcriptional factor;p73(7161)

"These results suggest that the expression of PAP2a is directly regulated by p73." (17169329)

phosphorylation;

O14494

phosphorylation;

O14495

phosphorylation;

O43688

phosphorylation;

Q6T4P5

phosphorylation;

O14495:from_uniprot:110_Phosphotyrosine

phosphorylation;

Q7Z2D5:from_uniprot:217_Phosphoserine

phosphorylation;

Q7Z2D5:from_uniprot:346_Phosphoserine

phosphorylation;

Q7Z2D5:from_uniprot:416_Phosphothreonine

Gene ontology

Gene ontology

GO:0046839 (P) phospholipid dephosphorylation [O14494 ];
GO:0005624 (C) membrane fraction [O14494 ];
GO:0030521 (P) androgen receptor signaling pathway [O14494 ];
GO:0008285 (P) negative regulation of cell proliferation [O14494 ];
GO:0005886 (C) plasma membrane [O14495 ];
GO:0008354 (P) germ cell migration [O14494, O14495 ];
GO:0005829 (C) cytosol [O14494, O14495, O43688 ];
GO:0005794 (C) Golgi apparatus [O14495 ];
GO:0019216 (P) regulation of lipid metabolic process [O14494 ];
GO:0016021 (C) integral to membrane [Q7Z2D5, O14495, Q96GM1, Q6T4P5, O43688 ];
GO:0005887 (C) integral to plasma membrane [O14494 ];
GO:0004721 (F) phosphoprotein phosphatase activity [O14495, O43688 ];
GO:0008195 (F) phosphatidate phosphatase activity [Q7Z2D5, O14494, O14495, Q96GM1, Q6T4P5, O43688 ];
GO:0007205 (P) activation of protein kinase C activity [O14494 ];

Tissue expression

Tissue From HPRD

Thymus [06179 ];
Colon [06178, 06179 ];
Fetus [06180 ];
Leukocyte [06179 ];
Testis [06178, 06179 ];
Skeletal muscle [06178, 06179 ];
Liver [06178, 06179 ];
Blood [06179 ];
Brain [06178, 06179 ];
Spleen [06178, 06179 ];
Prostate [06178, 06179 ];
Small intestine [06178, 06179 ];
Kidney [06178, 06179 ];
Lung [06178, 06179 ];
Heart [06178, 06179 ];
Pancreas [06178, 06179, 06180 ];
Ovary [06178, 06179 ];
Placenta [06179, 06180 ];

Tissue specificity

Found mainly in brain, pancreas and placenta [O43688 ];

Specifically expressed in neurons [Q7Z2D5 ];

Ubiquitously expressed with highest expression found in prostate. Isoform 1 is predominant in kidney, lung, placenta and liver;
isoform 2 is predominant in heart and pancreas. Found to be down-regulated in colon adenocarcinomas [O14494 ];

Ubiquitously expressed. Highly expressed in heart and placenta [O14495 ];

Subcellular localization

Localization

cell membrane [O14494 ];

golgi apparatus [O14495 ];

membrane [Q7Z2D5, O14495, Q96GM1, Q6T4P5, O43688 ];

Links

SwissProt

O14494; O14495; O43688; Q6T4P5; Q7Z2D5; Q96GM1

Entrez Gene

8611; 8612; 8613

HPRD

06179; 06178; 06180



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min