Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

4.1.1.50

Official Name

adenosylmethionine decarboxylase

Name from literature

S-Adenosylmethionine decarboxylase

Pathway from literature

polyamine biosynthesis pathway

Pathway from KEGG

Amino Acid Metabolism; Urea cycle and metabolism of amino groups; map00220

Amino Acid Metabolism; Methionine metabolism; map00271

Organisms

Human (9606)

Genome localization

6q21-q22[262 ],

Comments

The Escherichia coli enzyme contains a pyruvoyl group.

Rate-limiting Description

"The rate-limiting enzymes in polyamine biosynthesis, ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC), are negatively regulated by the polyamines spermidine and spermine." (2775206)

"S-Adenosylmethionine decarboxylase (AdoMetDC), a rate-limiting enzyme in polyamine biosynthesis, is regulated by polyamines at the levels of both transcription and translation." (7945201)

"The two rate-limiting synthetic enzymes were also present, and their activities were stimulated dramatically by addition of serum to the culture medium." (11923270)

Regulatory Information

Regulatory type

Detail

regulatory enzyme;

"S-Adenosylmethionine decarboxylase (AdoMetDC) is a critical regulatory enzyme of the polyamine synthetic pathway, and a well-studied drug target." (10378277)

phosphorylation;

P17707

Gene ontology

Gene ontology

GO:0008295 (P) spermidine biosynthetic process [Q5VXN5, P17707 ];
GO:0006597 (P) spermine biosynthetic process [Q5VXN5, P17707 ];
GO:0004014 (F) adenosylmethionine decarboxylase activity [Q5VXN5, P17707 ];

Links

SwissProt

P17707; Q5VXN5

Entrez Gene

262

HPRD

01622



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  Last Modified: 2009-03-24  
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