Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

4.1.1.22

Official Name

histidine decarboxylase

Name from literature

histidine decarboxylase

Pathway from literature

histamine synthesis

Pathway from KEGG

Amino Acid Metabolism; Histidine metabolism; map00340

Organisms

Human (9606)

Genome localization

15q21-q22[3067 ],

Comments

A pyridoxal-phosphate protein (in animal tissues). The bacterial enzyme has a pyruvoyl residue as prosthetic group.

Rate-limiting Description

"We investigated the localization of histidine decarboxylase (HDC), which is the rate-limiting enzyme that generates histamine from histidine, in human aorta/coronary artery." (11566179)

Regulatory Information

Upstream transcription factor

9314

Regulatory type

Detail

key enzyme;

"Histidine decarboxylase (HDC) is the key enzyme for gastric histamine synthesis, and enhanced HDC expression is critically involved in the pathogenesis of gastric disorders, including gastroduodenal ulcer disease." (11790728)

transcriptional factor;kruppel-like factor 4(9314)

"Histidine decarboxylase promoter activity can be repressed by kruppel-like factor 4" (14670968)

regulatory enzyme;

"The results also support the idea that total starvation, and most likely, prolonged caloric restriction, like protein malnutrition, elicit increased formation of histamine in brain since the key regulatory enzyme, L-histidine carboxylase (EC 4.1.1.22) functions at less than maximal efficiency under normal brain levels of histidine." (3587507)

transcriptional factor;

"HDC expression is regulated by gastrin through a complex cis-acting element, which binds at least three distinct nuclear factors" (12372397)

Gene ontology

Gene ontology

GO:0030170 (F) pyridoxal phosphate binding [P19113 ];
GO:0004398 (F) histidine decarboxylase activity [P19113 ];
GO:0042423 (P) catecholamine biosynthetic process [P19113 ];

Links

SwissProt

P19113

Entrez Gene

3067

HPRD

00817



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  Last Modified: 2009-03-24  
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