Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

5.4.99.7

Official Name

lanosterol synthase

Name from literature

oxido:lanosterol cyclase/Oxidosqualene--lanosterol cyclase

Pathway from literature

cholesterol biosynthetic pathway

Pathway from KEGG

Lipid Metabolism; Biosynthesis of steroids; map00100

Organisms

Human (9606)

Genome localization

21q22.3[4047 ],

Rate-limiting Description

"This hypocholesterolemic effect was likely due to the inhibition of the oxido:lanosterol cyclase (OSC), a rate-limiting enzyme in the cholesterol biosynthetic pathway." (15763540)

Regulatory Information

Upstream transcription factor

8841

Regulatory type

Detail

others;

"two crystal structures of the human membrane protein OSC: the target protein with an inhibitor that showed cholesterol lowering in vivo opens the way for the structure-based design of new OSC inhibitors." (15525992)

transcriptional factor;HDAC3(8841)

"Here, we report that histone deacetylase 3 (HDAC3) represses transcription from the lanosterol synthase promoter." (17925399)

others;

"Regulation of squalene synthetase in human hepatoma cell line Hep G2 by sterols, and not by mevalonate-derived non-sterols." (2538145)

Gene ontology

Gene ontology

GO:0016829 (F) lyase activity [P48449 ];
GO:0006694 (P) steroid biosynthetic process [P48449 ];
GO:0000250 (F) lanosterol synthase activity [P48449 ];

Links

SwissProt

P48449

Entrez Gene

4047

HPRD

02945



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  Last Modified: 2009-03-24  
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