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Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases |
Basic Information |
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Enzyme Number | 1.1.1.49 |
Official Name | glucose-6-phosphate dehydrogenase |
Name from literature | glucose-6-phosphate dehydrogenase |
Pathway from literature | pentose phosphate pathway (PPP)/the GSH- and NADPH-dependent H(2)O(2) elimination by PC12 cells/NADPH production |
Pathway from KEGG |
Metabolism of Other Amino Acids; Glutathione metabolism; map00480 |
Carbohydrate Metabolism; Pentose phosphate pathway; map00030 | |
Organisms | Human (9606) |
Genome localization | Xq28[2539 ], |
Comments | Also acts slowly on beta-D-glucose and other sugars. Certain preparations reduce NAD+ as well as NADP+. |
Rate-limiting Description | "Furthermore, the activity and transcript level of the lipogenic enzyme glucose-6-phosphate dehydrogenase, the rate-limiting enzyme of the pentose phosphate pathway, were also about 2-fold higher than that of the wild-type; these data corroborate the flux analysis results." (18029214) |
| "The principal intracellular reductant NADPH is mainly produced by the pentose phosphate pathway by glucose-6-phosphate dehydrogenase (G6PDH), the rate-limiting enzyme, and by 6-phosphogluconate dehydrogenase." (10329961) |
Regulatory Information |
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Upstream transcription factor | |
Regulatory type | Detail |
key enzyme; | "Glucose-6-phosphate dehydrogenase (G6PD), the key enzyme of the hexose-monophosphate shunt pathway, is an essential enzyme involved in both cell growth and cholesterol metabolism, raising the question as to whether G6PD deficiency may have metabolic and growth implications in a deficient population." (12027950) |
phosphorylation; | "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules." (15951569#15592455) |
regulatory enzyme; | "We review here some recent data about glucose-6-phosphate dehydrogenase (G6PD), the first and key regulatory enzyme of the pentose phosphate pathway." (8760336) |
transcriptional factor;CREB(1385) | "We have shown two distinct CREB-responsive sites in the glucose-6-phosphatase gene promoter that are responding to a constitutively active CREB or elevated concentrations of the catalytic subunit of cAMP-dependent protein kinase in the nucleus." (15659240) |
phosphorylation; | P11413 |
phosphorylation; | P11413:from_uniprot:401_Phosphotyrosine |
phosphorylation; | P11413:from_uniprot:503_Phosphotyrosine |
phosphorylation; | P11413:from_uniprot:507_Phosphotyrosine |
Gene ontology |
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Gene ontology |
GO:0005536 (F) glucose binding [P11413 ]; |
Tissue expression |
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Tissue From HPRD |
Hematopoietic stem cell [02377 ]; |
Tissue specificity |
The long isoform is found in lymphoblasts, granulocytes and sperm [P11413 ]; |
Disease relevance |
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Disease |
Defects in G6PD are the cause of chronic non-spherocytic hemolytic anemia (CNSHA) [MIM:305900]. Deficiency of G6PD is associated with hemolytic anemia in two different situations. First, in areas in which malaria has been endemic, G6PD-deficiency alleles have reached high frequencies (1% to 50%) and deficient individuals, though essentially asymptomatic in the steady state, have a high risk of acute hemolytic attacks. Secondly, sporadic cases of G6PD deficiency occur at a very low frequencies, and they usually present a more severe phenotype. Several types of CNSHA are recognized. Class-I variants are associated with severe NSHA; |
Links |
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SwissProt | |
Entrez Gene | |
HPRD |
Copyright 2009, Center for Bioinformatics | |||
Last Modified: 2009-03-24 | |||
Design by Zhao Min |