Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.7.4.9

Official Name

dTMP kinase

Name from literature

deoxythymidylate kinase

Pathway from literature

the biosynthesis of deoxythymidine triphosphate

Pathway from KEGG

Nucleotide Metabolism; Pyrimidine metabolism; map00240

Organisms

Human (9606)

Genome localization

2q37.3[1841 ],

Rate-limiting Description

"Thus, in the infected cell deoxythymidylate kinase is a rate-limiting enzyme in the biosynthesis of deoxythymidine triphosphate." (164949)

Regulatory Information

Regulatory type

Detail

key enzyme;

"Novel nucleotide analogues as potential substrates for TMPK, a key enzyme in the metabolism of AZT." (14565287#18413751)

others;

"Our results suggest that the expression of the dTMP kinase gene and its activity coincide with various stages of cell growth." (8024690)

Gene ontology

Gene ontology

GO:0008283 (P) cell proliferation [P23919 ];
GO:0004798 (F) thymidylate kinase activity [P23919 ];
GO:0007049 (P) cell cycle [P23919 ];
GO:0005829 (C) cytosol [P23919 ];
GO:0005524 (F) ATP binding [P23919 ];
GO:0006233 (P) dTDP biosynthetic process [P23919 ];
GO:0019206 (F) nucleoside kinase activity [P23919 ];
GO:0006235 (P) dTTP biosynthetic process [P23919 ];

Links

SwissProt

P23919

Entrez Gene

1841

HPRD

01773



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  Last Modified: 2009-03-24  
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