Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.1.3.2

Official Name

aspartate carbamoyltransferase

Name from literature

Aspartate Carbamoyltransferase

Pathway from literature

pyrimidine nucleotide biosynthesis

Pathway from KEGG

Amino Acid Metabolism; Alanine and aspartate metabolism; map00252

Nucleotide Metabolism; Pyrimidine metabolism; map00240

Organisms

Human (9606)

Genome localization

2p22-p21[790 ],

Rate-limiting Description

"Recent studies demonstrate that CAD, a rate-limiting enzyme in the de novo synthesis of pyrimidines, is regulated through reversible phosphorylation, Myc-dependent transcriptional changes and caspase-mediated degradation." (12678497)

Regulatory Information

Upstream transcription factor

6667;3091

Regulatory type

Detail

transcriptional factor;HIF-1alpha(3091)

"Transcriptional repression of human cad gene by hypoxia inducible factor-1alpha." (16155188)

inhibitor;

"ACTase inhibition by N-(phosphonacetyl)-l-aspartate (PALA) was consistent with a competitive model with respect to carbamoyl phosphate." (8292811)

transcriptional factor;Sp-1(6667)

"the cad gene is regulated by a nonclassical ERalpha/Sp1-mediated pathway." (12746293)

phosphorylation;

P27708

phosphorylation;

P27708:from_uniprot:1423_Phosphoserine

phosphorylation;

P27708:from_uniprot:1823_Phosphoserine

phosphorylation;

P27708:from_uniprot:1859_Phosphoserine

Gene ontology

Gene ontology

GO:0016597 (F) amino acid binding [P27708 ];
GO:0008270 (F) zinc ion binding [P27708 ];
GO:0004151 (F) dihydroorotase activity [P27708 ];
GO:0006207 (P) 'de novo' pyrimidine base biosynthetic process [P27708 ];
GO:0004088 (F) carbamoyl-phosphate synthase (glutamine-hyd... [P27708 ];
GO:0004070 (F) aspartate carbamoyltransferase activity [P27708 ];
GO:0005829 (C) cytosol [P27708 ];
GO:0006221 (P) pyrimidine nucleotide biosynthetic process [P27708 ];
GO:0005524 (F) ATP binding [P27708 ];
GO:0006541 (P) glutamine metabolic process [P27708 ];

Subcellular localization

Localization

cytoplasm [P27708 ];

Links

Entrez Gene

790

HPRD

06437



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  Last Modified: 2009-03-24  
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