Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.7.1.40

Official Name

pyruvate kinase

Name from literature

pyruvate kinase

Pathway from literature

glycolysis

Pathway from KEGG

Human Diseases; Metabolic Disorders; Type II diabetes mellitus; map04930

Cellular Processes; Endocrine System; Insulin signaling pathway; map04910

Carbohydrate Metabolism; Pyruvate metabolism; map00620

Nucleotide Metabolism; Purine metabolism; map00230

Carbohydrate Metabolism; Glycolysis / Gluconeogenesis; map00010

Energy Metabolism; Carbon fixation; map00710

Organisms

Mouse (10090)

Genome localization

3 F1|3 44.0 cM[18770 ], 9 B|9 52.0 cM[18746 ],

Comments

UTP, GTP, CTP, ITP and dATP can also act as donors. Also phosphorylates hydroxylamine and fluoride in the presence of CO2.

Rate-limiting Description

"Evidence from transgenic mice that glucokinase is rate limiting for glucose utilization in the liver." (8751724)

Regulatory Information

Upstream transcription factor

15376

Regulatory type

Detail

phosphorylation;

P52480

phosphorylation;

P53657

phosphorylation;

P52480:from_uniprot:105_Phosphotyrosine

phosphorylation;

P52480:from_uniprot:148_Phosphotyrosine

phosphorylation;

P52480:from_uniprot:328_Phosphothreonine

phosphorylation;

P52480:from_uniprot:37_Phosphoserine

phosphorylation;

P52480:from_uniprot:390_Phosphotyrosine

phosphorylation;

P52480:from_uniprot:45_Phosphothreonine

phosphorylation;

P52480:from_uniprot:83_Phosphotyrosine

phosphorylation;

P53657:from_uniprot:43_Phosphoserine; by PKA

phosphorylation;

P53657:from_uniprot:556_Phosphothreonine

transcriptional factor;Foxa2(15376)

"Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes." (15616563)

Gene ontology

Gene ontology

GO:0000287 (F) magnesium ion binding [Q3UEI4, P53657, A7MCU9, P52480, Q3UEH4 ];
GO:0004743 (F) pyruvate kinase activity [Q3UEI4, P53657, A7MCU9, P52480, Q3UEH4 ];
GO:0005739 (C) mitochondrion [P52480 ];
GO:0006096 (P) glycolysis [Q3UEI4, P53657, A7MCU9, P52480, Q3UEH4 ];
GO:0051707 (P) response to other organism [P53657 ];
GO:0030955 (F) potassium ion binding [Q3UEI4, P53657, A7MCU9, P52480, Q3UEH4 ];
GO:0005515 (F) protein binding [P52480 ];
GO:0019861 (C) flagellum [P52480 ];

Links

SwissProt

A7MCU9; P52480; P53657; Q3UEH4; Q3UEI4

Entrez Gene

18746; 18770



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min