Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.1.85

Official Name

fatty-acid synthase

Name from literature

fatty acid synthase

Pathway from literature

fatty acid biosynthetic pathway

Pathway from KEGG

Cellular Processes; Endocrine System; Insulin signaling pathway; map04910

Lipid Metabolism; Fatty acid biosynthesis; map00061

Organisms

Rat (10116)

Genome localization

-[50671 ],

Comments

The animal enzyme is a multi-functional protein catalysing the reactions of EC 2.3.1.38 [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39 [acyl-carrier-protein] S-malonyltransferase, EC 2.3.1.41 3-oxoacyl-[acyl-carrier-protein] synthase, EC 1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase, EC 4.2.1.61 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) and EC 3.1.2.14 oleoyl-[acyl-carrier-protein] hydrolase.

Rate-limiting Description

"INTRODUCTION: The purpose of this study was to investigate whether chronic exercise training attenuates fatty acid synthase, the rate-limiting enzyme for hepatic lipogenesis, and the accumulation of body fat by using obese Zucker rats (OZR) as a model." (12131249)

Regulatory Information

Upstream transcription factor

25735;78968;25747

Regulatory type

Detail

phosphorylation;

P12785:from_uniprot:207_Phosphoserine

phosphorylation;

P12785:from_uniprot:2230_Phosphoserine

transcriptional factor;

"Transcription factors act on the promoter of the rat fatty acid synthase gene [review]" (12440974)

transcriptional factor;HNF4alpha(25735)

"These observations establish for the first time that HNF-4alpha functions in vivo through a direct repeat-1 (DR-1) element in the distal FAS promoter to enhance gene transcription following refeeding of glucose to fasted rats." (16800817)

transcriptional factor;SREBP-1c(78968)

"These results showed that increases in SREBP-1c were neither necessary nor sufficient for Glucokinase induction in hepatocytes, while at the same time they underscored the role of SREBP-1c as a key regulator of Fatty acid synthase." (16834571)

transcriptional factor;SREBP-1c(78968)

"polyunsaturated fatty acids decrease in vivo binding of NF-Y and SREBP-1c to the proximal promoter of the hepatic Fasn gene" (17313375)

transcriptional factor;SREBP-1c(78968)

"Insulin, glucose and AICAR (an activator of AMP-activated protein kinase) affected changes in hypothalamic FAS mRNA, which may be regulated via the SREBP1c dependent or independent pathway." (17709201)

transcriptional factor;PPARalpha(25747)

"PPARalpha is required to mediate the response of Scd-1 and Fas gene expression to insulin and that this is normally achieved directly by activation of LXRalpha." (18079124)

Gene ontology

Gene ontology

GO:0048037 (F) cofactor binding [P12785 ];
GO:0031177 (F) phosphopantetheine binding [P12785 ];
GO:0008270 (F) zinc ion binding [P12785 ];
GO:0004313 (F) [acyl-carrier-protein] S-acetyltransferase ... [P12785 ];
GO:0004319 (F) enoyl- [acyl-carrier-protein] reductase (NAD... [P12785 ];
GO:0004315 (F) 3-oxoacyl- [acyl-carrier-protein] synthase a... [P12785 ];
GO:0006633 (P) fatty acid biosynthetic process [P12785 ];
GO:0004317 (F) 3-hydroxypalmitoyl- [acyl-carrier-protein] d... [P12785 ];
GO:0000036 (F) acyl carrier activity [P12785 ];
GO:0004320 (F) oleoyl- [acyl-carrier-protein] hydrolase act... [P12785 ];
GO:0042802 (F) identical protein binding [P12785 ];
GO:0004314 (F) [acyl-carrier-protein] S-malonyltransferase... [P12785 ];
GO:0055114 (P) oxidation reduction [P12785 ];
GO:0042470 (C) melanosome [P12785 ];
GO:0004316 (F) 3-oxoacyl- [acyl-carrier-protein] reductase ... [P12785 ];

Subcellular localization

Localization

cytoplasm [P12785 ];

Links

SwissProt

P12785

Entrez Gene

50671



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  Last Modified: 2009-03-24  
  Design by Zhao Min