Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

4.2.1.1

Official Name

carbonate dehydratase

Name from literature

carbonic anhydrase

Pathway from literature

CO2 hydration

Pathway from KEGG

Energy Metabolism; Nitrogen metabolism; map00910

Organisms

Rat (10116)

Genome localization

2q23[54232 ], 2q23[54231 ], 19q12[54233 ], 10q26[29242 ],

Comments

A zinc protein.

Rate-limiting Description

"Acetazolamide-pretreated rats had the same CO2 uptake as controls after 15 min exposure to CO2, rather than lower uptake as would be expected if carbonic anhydrase were rate-limiting." (6772280)

Regulatory Information

Upstream transcription factor

290215;29663

Regulatory type

Detail

phosphorylation;

P27139:from_uniprot:87_Phosphoserine

transcriptional factor;AP-1(171494,29663,360785,290215,306332)

"Carbonic anhydrase II is an AP-1 target gene in osteoclasts." (11382925)

Gene ontology

Gene ontology

GO:0008270 (F) zinc ion binding [Q66HG6, P48284, P43165, P27139, P14141, B0BNN3 ];
GO:0004089 (F) carbonate dehydratase activity [Q66HG6, P48284, P43165, P27139, P14141, B0BNN3 ];
GO:0031225 (C) anchored to membrane [P48284 ];
GO:0005739 (C) mitochondrion [Q66HG6, P43165 ];
GO:0005886 (C) plasma membrane [P48284 ];
GO:0006730 (P) one-carbon compound metabolic process [Q66HG6, P48284, P43165, P27139, P14141, B0BNN3 ];
GO:0005737 (C) cytoplasm [P27139, P14141, B0BNN3 ];

Subcellular localization

Localization

cell membrane [P48284 ];

mitochondrion [Q66HG6, P43165 ];

cytoplasm [P27139, P14141, B0BNN3 ];

Links

SwissProt

B0BNN3; P14141; P27139; P43165; P48284; Q66HG6

Entrez Gene

29242; 54231; 54232; 54233



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min