Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.2.1.36

Official Name

retinal dehydrogenase

Name from literature

retinal dehydrogenase

Pathway from literature

the metabolism of retinal to retinoic acid

Pathway from KEGG

Metabolism of Cofactors and Vitamins; Retinol metabolism; map00830

Organisms

Rat (10116)

Genome localization

8q24[116676 ], 1q51[24188 ],

Comments

A metalloflavoprotein (FAD). Acts on both the 11-trans- and 13-cis-forms of retinal.

Rate-limiting Description

"Under conditions in which retinal dehydrogenase activity is rate-limiting for the metabolism of retinal to retinoic acid, its induction after phenobarbital or ethanol administration may contribute to hepatic vitamin A depletion." (2910311)

Regulatory Information

Upstream transcription factor

686530

Regulatory type

Detail

phosphorylation;

Q63639:from_uniprot:119_Phosphothreonine

phosphorylation;

Q63639:from_uniprot:122_Phosphothreonine

transcriptional factor;Oct-1,CBF-A(686530)

"Characterization of the rat RALDH1 promoter. A functional CCAAT and octamer motif are critical for basal promoter activity." (12427543)

transcriptional level;"HNF-4,HNF-1alpha"

"These results suggest that postnatal expressions of hepatocyte-specific genes might be up-regulated by retinoid receptors, which may be related with the alterations of RALDH expression during postnatal development in the liver." (14729401)

Gene ontology

Gene ontology

GO:0001758 (F) retinal dehydrogenase activity [Q63639, P51647 ];
GO:0055114 (P) oxidation reduction [Q63639, P51647 ];
GO:0005737 (C) cytoplasm [Q63639, P51647 ];

Subcellular localization

Localization

cytoplasm [Q63639, P51647 ];

Links

SwissProt

P51647; Q63639

Entrez Gene

116676; 24188



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min