Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.1.87

Official Name

aralkylamine N-acetyltransferase

Name from literature

arylalkylamine N-acetyltransferase

Pathway from literature

melatonin synthesis

Pathway from KEGG

Amino Acid Metabolism; Tryptophan metabolism; map00380

Organisms

Rat (10116)

Genome localization

10q32.3[25120 ],

Comments

Narrow specificity towards 2-arylethylamines, including serotonin (5-hydroxytryptamine), tryptamine, 5-methoxytryptamine and phenylethylamine. This is the penultimate enzyme in the production of melatonin (5-methoxy-N-acetyltryptamine) and controls its synthesis (cf. EC 2.1.1.4, acetylserotonin O-methyltransferase). Differs from EC 2.3.1.5 arylamine N-acetyltransferase.

Rate-limiting Description

"Presently, we find the expression of the serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT) mRNA, the rate-limiting enzyme in the conversion of serotonin to melatonin, in the rat suprachiasmatic nucleus (SCN) which contains the biological circadian clock in mammals." (10329462)

Regulatory Information

Upstream transcription factor

24516;314322

Regulatory type

Detail

phosphorylation;

Q64666

transcriptional level;pancreatic melatonin (MT1) receptor

"Whereas the rat pancreatic mRNA expression of the MT1-receptor was significantly increased, the activity of the pineal AANAT enzyme was reduced." (16441550)

transcriptional factor;c-FOS(314322),c-JUN(24516)

"This finding suggests that the c-FOS/c-JUN dimer is required for transcriptional activation of the Aanat gene. " (16687308)

Gene ontology

Gene ontology

GO:0004059 (F) aralkylamine N-acetyltransferase activity [Q64666 ];
GO:0008152 (P) metabolic process [Q64666 ];

Links

SwissProt

Q64666

Entrez Gene

25120



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  Last Modified: 2009-03-24  
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