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Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases |
Basic Information |
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Enzyme Number | 1.2.4.2/2.3.1.61/1.8.1.4 |
Official Name | dihydrolipoyllysine-residue succinyltransferase |
Name from literature | oxoglutarate dehydrogenase complex |
Pathway from literature | citric acid cycle |
Pathway from KEGG |
Carbohydrate Metabolism; Pyruvate metabolism; map00620 |
Carbohydrate Metabolism; Glycolysis / Gluconeogenesis; map00010 | |
Carbohydrate Metabolism; Citrate cycle (TCA cycle); map00020 | |
Amino Acid Metabolism; Tryptophan metabolism; map00380 | |
Amino Acid Metabolism; Glycine, serine and threonine metabolism; map00260 | |
Amino Acid Metabolism; Valine, leucine and isoleucine degradation; map00280 | |
Amino Acid Metabolism; Lysine degradation; map00310 | |
Amino Acid Metabolism; Alanine and aspartate metabolism; map00252 | |
Organisms | Yeast (4932) |
Genome localization | |
Comments | A multimer (24-mer) of this enzyme forms the core of the multienzyme complex, and binds tightly both EC 1.2.4.2, oxoglutarate dehydrogenase (succinyl-transferring) and EC 1.8.1.4, dihydrolipoyl dehydrogenase. The lipoyl group of this enzyme is reductively succinylated by EC 1.2.4.2, and the only observed direction catalysed by EC 2.3.1.61 is that where this succinyl group is passed to coenzyme A. |
Rate-limiting Description | "Apparently, the deceleration of growth is due to a decrease in the activity of a thiamine-dependent enzyme (pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase or transketolase) which is a limiting point of biosynthetic processes." (502909) |
Regulatory Information |
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Regulatory type | Detail |
phosphorylation; | P20967:from_uniprot:901_Phosphotyrosine |
phosphorylation; | P20967:from_uniprot:901_Phosphotyrosine |
phosphorylation; | P20967:from_uniprot:901_Phosphotyrosine |
phosphorylation; | P19262:from_uniprot:340_Phosphothreonine |
phosphorylation; | P19262:from_uniprot:340_Phosphothreonine |
phosphorylation; | P19262:from_uniprot:340_Phosphothreonine |
Gene ontology |
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Gene ontology |
GO:0050660 (F) FAD binding [P09624 ]; |
Subcellular localization |
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Localization | |
Links |
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SwissProt | |
Entrez Gene |
Copyright 2009, Center for Bioinformatics | |||
Last Modified: 2009-03-24 | |||
Design by Zhao Min |