Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.2.4.2/2.3.1.61/1.8.1.4

Official Name

dihydrolipoyllysine-residue succinyltransferase

Name from literature

oxoglutarate dehydrogenase complex

Pathway from literature

citric acid cycle

Pathway from KEGG

Carbohydrate Metabolism; Pyruvate metabolism; map00620

Carbohydrate Metabolism; Glycolysis / Gluconeogenesis; map00010

Carbohydrate Metabolism; Citrate cycle (TCA cycle); map00020

Amino Acid Metabolism; Tryptophan metabolism; map00380

Amino Acid Metabolism; Glycine, serine and threonine metabolism; map00260

Amino Acid Metabolism; Valine, leucine and isoleucine degradation; map00280

Amino Acid Metabolism; Lysine degradation; map00310

Amino Acid Metabolism; Alanine and aspartate metabolism; map00252

Organisms

Yeast (4932)

Genome localization

-[856090 ], -[850527 ], -[854681 ], -[851726 ],

Comments

A multimer (24-mer) of this enzyme forms the core of the multienzyme complex, and binds tightly both EC 1.2.4.2, oxoglutarate dehydrogenase (succinyl-transferring) and EC 1.8.1.4, dihydrolipoyl dehydrogenase. The lipoyl group of this enzyme is reductively succinylated by EC 1.2.4.2, and the only observed direction catalysed by EC 2.3.1.61 is that where this succinyl group is passed to coenzyme A.

Rate-limiting Description

"Apparently, the deceleration of growth is due to a decrease in the activity of a thiamine-dependent enzyme (pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase or transketolase) which is a limiting point of biosynthetic processes." (502909)

Regulatory Information

Regulatory type

Detail

phosphorylation;

P20967:from_uniprot:901_Phosphotyrosine

phosphorylation;

P20967:from_uniprot:901_Phosphotyrosine

phosphorylation;

P20967:from_uniprot:901_Phosphotyrosine

phosphorylation;

P19262:from_uniprot:340_Phosphothreonine

phosphorylation;

P19262:from_uniprot:340_Phosphothreonine

phosphorylation;

P19262:from_uniprot:340_Phosphothreonine

Gene ontology

Gene ontology

GO:0050660 (F) FAD binding [P09624 ];
GO:0006564 (P) L-serine biosynthetic process [P09624 ];
GO:0006096 (P) glycolysis [P20967 ];
GO:0042645 (C) mitochondrial nucleoid [P09624, P20967, P19262 ];
GO:0004148 (F) dihydrolipoyl dehydrogenase activity [P09624 ];
GO:0004375 (F) glycine dehydrogenase (decarboxylating) act... [P09624 ];
GO:0031405 (F) lipoic acid binding [P19262 ];
GO:0006099 (P) tricarboxylic acid cycle [P20967, P19262 ];
GO:0009055 (F) electron carrier activity [P09624 ];
GO:0006546 (P) glycine catabolic process [P09624 ];
GO:0009353 (C) mitochondrial oxoglutarate dehydrogenase co... [P09624, P20967, P19262 ];
GO:0045454 (P) cell redox homeostasis [P09624 ];
GO:0005515 (F) protein binding [P09624, P19262 ];
GO:0004591 (F) oxoglutarate dehydrogenase (succinyl-transf... [P09624, P20967 ];
GO:0030976 (F) thiamin pyrophosphate binding [P20967 ];
GO:0005960 (C) glycine cleavage complex [P09624 ];
GO:0006090 (P) pyruvate metabolic process [P09624 ];
GO:0006552 (P) leucine catabolic process [P09624 ];
GO:0006574 (P) valine catabolic process [P09624 ];
GO:0042743 (P) hydrogen peroxide metabolic process [P09624 ];
GO:0004738 (F) pyruvate dehydrogenase activity [P09624 ];
GO:0006550 (P) isoleucine catabolic process [P09624 ];
GO:0006103 (P) 2-oxoglutarate metabolic process [P09624, P20967, P19262 ];
GO:0055114 (P) oxidation reduction [P09624, P20967 ];
GO:0004149 (F) dihydrolipoyllysine-residue succinyltransfe... [P19262 ];

Subcellular localization

Localization

mitochondrion [P09624, P20967, P19262 ];

Links

SwissProt

P20967; P09624; P19262

Entrez Gene

854681; 850527; 856090; 851726



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min