1.2.4.2/2.3.1.61/1.8.1.4

dihydrolipoyllysine-residue succinyltransferase

oxoglutarate dehydrogenase complex

citric acid cycle

Yeast (4932)

-[856090 ], -[850527 ], -[854681 ], -[851726 ],

A multimer (24-mer) of this enzyme forms the core of the multienzyme complex, and binds tightly both EC 1.2.4.2, oxoglutarate dehydrogenase (succinyl-transferring) and EC 1.8.1.4, dihydrolipoyl dehydrogenase. The lipoyl group of this enzyme is reductively succinylated by EC 1.2.4.2, and the only observed direction catalysed by EC 2.3.1.61 is that where this succinyl group is passed to coenzyme A.

"Apparently, the deceleration of growth is due to a decrease in the activity of a thiamine-dependent enzyme (pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase or transketolase) which is a limiting point of biosynthetic processes." (502909)

phosphorylation;

phosphorylation;

phosphorylation;

phosphorylation;

phosphorylation;

phosphorylation;

GO:0050660 (F) FAD binding [P09624 ];
GO:0006564 (P) L-serine biosynthetic process [P09624 ];
GO:0006096 (P) glycolysis [P20967 ];
GO:0042645 (C) mitochondrial nucleoid [P09624, P20967, P19262 ];
GO:0004148 (F) dihydrolipoyl dehydrogenase activity [P09624 ];
GO:0004375 (F) glycine dehydrogenase (decarboxylating) act... [P09624 ];
GO:0031405 (F) lipoic acid binding [P19262 ];
GO:0006099 (P) tricarboxylic acid cycle [P20967, P19262 ];
GO:0009055 (F) electron carrier activity [P09624 ];
GO:0006546 (P) glycine catabolic process [P09624 ];
GO:0009353 (C) mitochondrial oxoglutarate dehydrogenase co... [P09624, P20967, P19262 ];
GO:0045454 (P) cell redox homeostasis [P09624 ];
GO:0005515 (F) protein binding [P09624, P19262 ];
GO:0004591 (F) oxoglutarate dehydrogenase (succinyl-transf... [P09624, P20967 ];
GO:0030976 (F) thiamin pyrophosphate binding [P20967 ];
GO:0005960 (C) glycine cleavage complex [P09624 ];
GO:0006090 (P) pyruvate metabolic process [P09624 ];
GO:0006552 (P) leucine catabolic process [P09624 ];
GO:0006574 (P) valine catabolic process [P09624 ];
GO:0042743 (P) hydrogen peroxide metabolic process [P09624 ];
GO:0004738 (F) pyruvate dehydrogenase activity [P09624 ];
GO:0006550 (P) isoleucine catabolic process [P09624 ];
GO:0006103 (P) 2-oxoglutarate metabolic process [P09624, P20967, P19262 ];
GO:0055114 (P) oxidation reduction [P09624, P20967 ];
GO:0004149 (F) dihydrolipoyllysine-residue succinyltransfe... [P19262 ];

mitochondrion [P09624, P20967, P19262 ];

P20967; P09624; P19262

854681; 850527; 856090; 851726