Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.1.1.17

Official Name

phosphatidylethanolamine N-methyltransferase

Name from literature

phospholipid n methyltransferase I

Pathway from literature

Conversion of PE to PME and PME to PC in the presence of S-adenosyl-L-methionine/catecholamine pathway and production of epinephrine

Pathway from KEGG

Amino Acid Metabolism; Glycine, serine and threonine metabolism; map00260

Lipid Metabolism; Glycerophospholipid metabolism; map00564

Organisms

Rat (10116)

Genome localization

10q22[25511 ],

Rate-limiting Description

"Conversion of PE to PME and PME to PC in the presence of S-adenosyl-L-methionine (SAM) are catalyzed by two phospholipid N-methyltransferases, PMT I and PMT II, of which PMT I is the rate limiting enzyme." (8207329)

"The enzymes tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) catalyze the rate-limiting step in the catecholamine pathway and production of epinephrine, respectively." (9380436)

Gene ontology

Gene ontology

GO:0031966 (C) mitochondrial membrane [Q08388 ];
GO:0008654 (P) phospholipid biosynthetic process [Q08388 ];
GO:0016021 (C) integral to membrane [Q08388 ];
GO:0004608 (F) phosphatidylethanolamine N-methyltransferas... [Q08388 ];
GO:0005789 (C) endoplasmic reticulum membrane [Q08388 ];

Subcellular localization

Localization

mitochondrion [Q08388 ];

endoplasmic reticulum [Q08388 ];

Links

SwissProt

Q08388

Entrez Gene

25511



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  Last Modified: 2009-03-24  
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