Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.1.1.49

Official Name

glucose-6-phosphate dehydrogenase

Name from literature

glucose-6-phosphate dehydrogenase

Pathway from literature

pentose phosphate pathway (PPP)/the GSH- and NADPH-dependent H(2)O(2) elimination by PC12 cells/NADPH production

Pathway from KEGG

Metabolism of Other Amino Acids; Glutathione metabolism; map00480

Carbohydrate Metabolism; Pentose phosphate pathway; map00030

Organisms

Rat (10116)

Genome localization

Xq37[24377 ],

Comments

Also acts slowly on beta-D-glucose and other sugars. Certain preparations reduce NAD+ as well as NADP+.

Rate-limiting Description

"Treatment of cultured rat astrocytes with lipopolysaccharide (LPS; 1 microg/ml) increased mRNA expression of glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting step in the pentose phosphate pathway (PPP), in a time-dependent fashion (0-24 h)." (10098886)

Regulatory Information

Regulatory type

Detail

phosphorylation;

P05370:from_uniprot:401_Phosphotyrosine

phosphorylation;

P05370:from_uniprot:503_Phosphotyrosine

phosphorylation;

P05370:from_uniprot:507_Phosphotyrosine

transcriptional level;TNFalpha(24835)

"Tumor necrosis factor alpha augments the expression of glucose-6-phosphate dehydrogenase in rat hepatic endothelial and Kupffer cells." (9042391#1855214)

Gene ontology

Gene ontology

GO:0006006 (P) glucose metabolic process [P05370 ];
GO:0004345 (F) glucose-6-phosphate dehydrogenase activity [P05370 ];
GO:0005488 (F) binding [P05370 ];
GO:0055114 (P) oxidation reduction [P05370 ];

Links

SwissProt

P05370

Entrez Gene

24377



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  Last Modified: 2009-03-24  
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