Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.7.1.2

Official Name

glucokinase

Name from literature

Glucokinase

Pathway from literature

glucose metabolis

Pathway from KEGG

Human Diseases; Metabolic Disorders; Type II diabetes mellitus; map04930

Cellular Processes; Endocrine System; Insulin signaling pathway; map04910

Carbohydrate Metabolism; Starch and sucrose metabolism; map00500

Carbohydrate Metabolism; Glycolysis / Gluconeogenesis; map00010

Human Diseases; Metabolic Disorders; Maturity onset diabetes of the young; map04950

Carbohydrate Metabolism; Galactose metabolism; map00052

Biosynthesis of Secondary Metabolites; Streptomycin biosynthesis; map00521

Organisms

Mouse (10090)

Genome localization

11 A1|11 1.0 cM[103988 ],

Comments

A group of enzymes found in invertebrates and microorganisms that are highly specific for glucose.

Rate-limiting Description

"Evidence from transgenic mice that glucokinase is rate limiting for glucose utilization in the liver." (8751724)

"Glucokinase catalyzes a rate-limiting step in glucose metabolism in hepatocytes and pancreatic beta cells and is considered the "glucose sensor" for regulation of insulin secretion." (7665557)

"As the rate-limiting controller of glucose metabolism, glucokinase represents the primary beta-cell "glucose sensor." Inactivation of both glucokinase (GK) alleles results in permanent neonatal diabetes; inactivation of a single allele causes maturity-onset diabetes of the young type 2 (MODY-2)." (16186394)

Regulatory Information

Upstream transcription factor

15379;58805;20787;15376

Regulatory type

Detail

transcriptional factor;HNF-6(15379)

"results show that although HNF-6 is not required to open chromatin of the hepatic promoter of the glucokinase gene, it stimulates transcription of the glucokinase gene in the liver" (12189444)

transcriptional factor;"ChREBP(58805),SREBP-1c(20787)"

"Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression" (14985368)

transcriptional factor;Foxa2(15376)

"Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes." (15616563)

Gene ontology

Gene ontology

GO:0045721 (P) negative regulation of gluconeogenesis [P52792 ];
GO:0005536 (F) glucose binding [P52792 ];
GO:0051594 (P) detection of glucose [P52792 ];
GO:0001678 (P) cellular glucose homeostasis [P52792 ];
GO:0046835 (P) carbohydrate phosphorylation [P52792 ];
GO:0043266 (P) regulation of potassium ion transport [P52792 ];
GO:0006096 (P) glycolysis [P52792 ];
GO:0005739 (C) mitochondrion [P52792 ];
GO:0005524 (F) ATP binding [P52792 ];
GO:0006739 (P) NADP metabolic process [P52792 ];
GO:0045725 (P) positive regulation of glycogen biosyntheti... [P52792 ];
GO:0005625 (C) soluble fraction [P52792 ];
GO:0032024 (P) positive regulation of insulin secretion [P52792 ];
GO:0004340 (F) glucokinase activity [P52792 ];
GO:0005515 (F) protein binding [P52792 ];

Links

SwissProt

P52792

Entrez Gene

103988



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  Last Modified: 2009-03-24  
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