Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

4.1.1.17

Official Name

ornithine decarboxylase

Name from literature

ornithine decarboxylase

Pathway from literature

polyamine metabolism

Pathway from KEGG

Metabolism of Other Amino Acids; Glutathione metabolism; map00480

Amino Acid Metabolism; Urea cycle and metabolism of amino groups; map00220

Organisms

Rat (10116)

Genome localization

6q16[24609 ],

Comments

A pyridoxal-phosphate protein.

Rate-limiting Description

"Ornithine decarboxylase (ODC) activity, the rate limiting step of polyamine synthesis, and levels of the diamine putrescine, the product of ornithine decarboxylase reaction, were analyzed in control (non-laminectomized) animals and at 2 and 4 h after laminectomy or compression injury at the L4 segmental level." (10320037)

Regulatory Information

Upstream transcription factor

24577

Regulatory type

Detail

phosphorylation;

P09057

phosphorylation;

P09057:from_uniprot:303_Phosphoserine; by CK2

transcriptional factor;

"activation of the testosterone/AR pathway remarkably induced a selective increase in ODC expression without affecting other enzymes. " (17371283)

transcriptional factor;Myc(24577)

"Myc represses transcription through recruitment of DNA methyltransferase corepressor." (15616584)

Gene ontology

Gene ontology

GO:0004586 (F) ornithine decarboxylase activity [P09057 ];
GO:0006596 (P) polyamine biosynthetic process [P09057 ];

Links

SwissProt

P09057

Entrez Gene

24609



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  Last Modified: 2009-03-24  
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