Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.2.1.7

Official Name

1-deoxy-D-xylulose-5-phosphate synthase

Name from literature

DXP synthase

Pathway from literature

synthesis of isopentenyl pyrophosphate

Pathway from KEGG

Lipid Metabolism; Biosynthesis of steroids; map00100

Organisms

E.coli (83333)

Genome localization

-[945060 ],

Comments

Requires thiamine diphosphate. The enzyme forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here).

Rate-limiting Description

"DXP (1-deoxy-D-xylulose-5-phosphate) synthase is encoded by dxs and participates in the rate-limiting step in the synthesis of isopentenyl pyrophosphate (IPP), a building block of lycopene." (15898075)

Gene ontology

Gene ontology

GO:0030145 (F) manganese ion binding [P77488 ];
GO:0000287 (F) magnesium ion binding [P77488 ];
GO:0009228 (P) thiamin biosynthetic process [P77488 ];
GO:0008661 (F) 1-deoxy-D-xylulose-5-phosphate synthase act... [P77488 ];
GO:0016114 (P) terpenoid biosynthetic process [P77488 ];

Links

SwissProt

P77488

Entrez Gene

945060



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  Last Modified: 2009-03-24  
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