Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

Official Name

acetyl-CoA carboxylase

Name from literature

acetyl CoA carboxylase

Pathway from literature

the de novo synthesis of lipids and cholesterol

Pathway from KEGG

Biosynthesis of Secondary Metabolites; Tetracycline biosynthesis; map00253

Cellular Processes; Endocrine System; Insulin signaling pathway; map04910

Carbohydrate Metabolism; Pyruvate metabolism; map00620

Carbohydrate Metabolism; Propanoate metabolism; map00640

Lipid Metabolism; Fatty acid biosynthesis; map00061


Rat (10116)

Genome localization

12q16[116719 ], 10q26[60581 ],


A biotinyl-protein. Also catalyses transcarboxylation; the plant enzyme also carboxylates propanonyl-CoA and butanoyl-CoA.

Rate-limiting Description

"Because acetyl-CoA carboxylase (ACC) is the rate-limiting enzyme for liver fatty acid biosynthesis and a key regulator of muscle fatty acid oxidation, we examined whether ACC plays a role in the accumulation of intracellular TG." (11978655)

"We studied the effect of troglitazone treatment on rat liver acetyl-CoA carboxylase (ACC), the key enzyme that catalyzes the formation of malonyl-CoA, the rate-limiting step in the synthesis of long chain fatty acids." (11205884)

"The enzyme acetyl-CoA carboxylase alpha (ACC-alpha) is rate-limiting for the synthesis of long-chain fatty acids de novo." (11485560)

"Changes in the concentration of malonyl-CoA in many tissues have been related to alterations in the activity of acetyl-CoA carboxylase (ACC), the rate-limiting enzyme in its formation." (12065578)

Regulatory Information

Upstream transcription factor


Regulatory type




transcriptional factor;SREBP1(78968)

"study provides evidence that acetyl-CoA carboxylase beta expression in liver is regulated at the transcriptional level by the direct interaction of sterol regulatory element binding protein-1 with promoter II" (12764144)


"Human leptin increased AMP-activated protein kinase-alpha and Acacb phosphorylation in rat skeletal muscle of lean, but not obese rats." (18255222)


"The citrate produced by mitochondria may modulate ACC phosphorylation in the hypothalamus, controlling food intake and coordinating a multiorgan network that controls glucose homeostasis and energy uptake through the adrenergic system." (18534630)

Gene ontology

Gene ontology

GO:0030145 (F) manganese ion binding [P11497 ];
GO:0009374 (F) biotin binding [P11497 ];
GO:0004075 (F) biotin carboxylase activity [P11497 ];
GO:0003989 (F) acetyl-CoA carboxylase activity [P11497 ];
GO:0005737 (C) cytoplasm [P11497 ];
GO:0006633 (P) fatty acid biosynthetic process [P11497 ];
GO:0005524 (F) ATP binding [P11497 ];

Subcellular localization


cytoplasm [P11497 ];




Entrez Gene

116719; 60581

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  Last Modified: 2009-03-24  
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