Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

6.4.1.2

Official Name

acetyl-CoA carboxylase

Name from literature

acetyl CoA carboxylase

Pathway from literature

the de novo synthesis of lipids and cholesterol

Pathway from KEGG

Biosynthesis of Secondary Metabolites; Tetracycline biosynthesis; map00253

Cellular Processes; Endocrine System; Insulin signaling pathway; map04910

Carbohydrate Metabolism; Pyruvate metabolism; map00620

Carbohydrate Metabolism; Propanoate metabolism; map00640

Lipid Metabolism; Fatty acid biosynthesis; map00061

Organisms

Rat (10116)

Genome localization

12q16[116719 ], 10q26[60581 ],

Comments

A biotinyl-protein. Also catalyses transcarboxylation; the plant enzyme also carboxylates propanonyl-CoA and butanoyl-CoA.

Rate-limiting Description

"Because acetyl-CoA carboxylase (ACC) is the rate-limiting enzyme for liver fatty acid biosynthesis and a key regulator of muscle fatty acid oxidation, we examined whether ACC plays a role in the accumulation of intracellular TG." (11978655)

"We studied the effect of troglitazone treatment on rat liver acetyl-CoA carboxylase (ACC), the key enzyme that catalyzes the formation of malonyl-CoA, the rate-limiting step in the synthesis of long chain fatty acids." (11205884)

"The enzyme acetyl-CoA carboxylase alpha (ACC-alpha) is rate-limiting for the synthesis of long-chain fatty acids de novo." (11485560)

"Changes in the concentration of malonyl-CoA in many tissues have been related to alterations in the activity of acetyl-CoA carboxylase (ACC), the rate-limiting enzyme in its formation." (12065578)

Regulatory Information

Upstream transcription factor

78968

Regulatory type

Detail

phosphorylation;

P11497

transcriptional factor;SREBP1(78968)

"study provides evidence that acetyl-CoA carboxylase beta expression in liver is regulated at the transcriptional level by the direct interaction of sterol regulatory element binding protein-1 with promoter II" (12764144)

phosphorylation;

"Human leptin increased AMP-activated protein kinase-alpha and Acacb phosphorylation in rat skeletal muscle of lean, but not obese rats." (18255222)

phosphorylation;

"The citrate produced by mitochondria may modulate ACC phosphorylation in the hypothalamus, controlling food intake and coordinating a multiorgan network that controls glucose homeostasis and energy uptake through the adrenergic system." (18534630)

Gene ontology

Gene ontology

GO:0030145 (F) manganese ion binding [P11497 ];
GO:0009374 (F) biotin binding [P11497 ];
GO:0004075 (F) biotin carboxylase activity [P11497 ];
GO:0003989 (F) acetyl-CoA carboxylase activity [P11497 ];
GO:0005737 (C) cytoplasm [P11497 ];
GO:0006633 (P) fatty acid biosynthetic process [P11497 ];
GO:0005524 (F) ATP binding [P11497 ];

Subcellular localization

Localization

cytoplasm [P11497 ];

Links

SwissProt

P11497

Entrez Gene

116719; 60581



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  Last Modified: 2009-03-24  
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