Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.1.87

Official Name

aralkylamine N-acetyltransferase

Name from literature

arylalkylamine N-acetyltransferase

Pathway from literature

melatonin synthesis

Pathway from KEGG

Amino Acid Metabolism; Tryptophan metabolism; map00380

Organisms

Mouse (10090)

Genome localization

11 E2|11 70.0 cM[11298 ],

Comments

Narrow specificity towards 2-arylethylamines, including serotonin (5-hydroxytryptamine), tryptamine, 5-methoxytryptamine and phenylethylamine. This is the penultimate enzyme in the production of melatonin (5-methoxy-N-acetyltryptamine) and controls its synthesis (cf. EC 2.1.1.4, acetylserotonin O-methyltransferase). Differs from EC 2.3.1.5 arylamine N-acetyltransferase.

Rate-limiting Description

"In this study, we investigated their function using mouse pineal glands, and found that expression of the arylalkylamine N-acetyltransferase (Aa-Nat, EC 2.3.1.87, the rate-limiting enzyme of melatonin synthesis) gene after adrenergic receptor stimulation depended on the time of day even in vitro (gating)." (15773915)

Regulatory Information

Regulatory type

Detail

phosphorylation;

O88816

Gene ontology

Gene ontology

GO:0004059 (F) aralkylamine N-acetyltransferase activity [O88816, Q9Z2W3, Q9QUP1 ];
GO:0004060 (F) arylamine N-acetyltransferase activity [O88816 ];
GO:0008152 (P) metabolic process [O88816 ];

Links

SwissProt

O88816; Q9QUP1; Q9Z2W3

Entrez Gene

11298



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  Last Modified: 2009-03-24  
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